I. Introduction CALCIUM 1 (Ca2+) ions are of critical importance for a variety of vital bodily
functions (1–4). Intra-and extracellular Ca2+ act in distinct but sometimes complementary …

The extracellular calcium (Ca _ o^ 2+)-sensing receptor (CaSR) was the first GPCR
identified whose principal physiological ligand is an ion, namely extracellular Ca 2+. It …

The hormonal regulation of uterine oxytocin receptors (OTR) during the establishment of
pregnancy and at parturition has been studied extensively, but little information is available …

Aim To investigate the expression of CaR in the human pancreas and to evaluate the
differences in responses of human insulinoma cells and normal rat islets to extracellular …

The parathyroid glands are of major importance in calcium homeostasis. Small changes in
the plasma calcium (Ca2+) concentration induce rapid changes in parathyroid hormone …

I. Introduction E XTRACELLULAR Ca2+ ([Ca2+] e) as well as intracellular calcium ([Ca2+] i)
play an essential role in stimulussecretion coupling in endocrine cells, stimulus-contraction …

1, 4-Dihydropyridine-sensitive voltage-dependent Ca2+ channels play a crucial role in the
extracellular Ca (2+)-sensing of calcitonin-secreting parafollicular cells of the thyroid (C …

Abstract Calcium (Ca 2+) ions serve a large variety of intra-and extracellular roles (1, 2).
Cytosolic free calcium ions (Ca i) are a key intracellular second messenger and cofactor for …

Context: Autoimmune polyendocrine syndrome type 1 (APS1) is characterised by multiple
autoimmune endocrinopathies and results from mutations in the AIRE (autoimmune …

An essential function of C-cells and parathyroid cells is to monitor the extracellular Ca 2+
concentration. The Ca 2+-dependent secretion of calcitonin (CT) and parathyroid hormone …