Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …

Chromones are a group of naturally occurring compounds that are ubiquitous in nature,
especially in plants. The word chromone is derived from the Greek word chroma, meaning …

This report evaluates the scientific literature on caffeine with respect to potential
cardiovascular outcomes, specifically relative risks of total cardiovascular disease (CVD) …

Cancer immunotherapy has shown remarkable progress in recent years. Nanocarriers, such
as liposomes, have favorable advantages with the potential to further improve cancer …

Stimulation of almost all mammalian cell types leads to the release of cellular ATP and
autocrine feedback through a diverse array of purinergic receptors. Depending on the types …

Adenosine is involved in a range of physiological and pathological effects through
membrane-bound receptors linked to G proteins. There are four subtypes of adenosine …

In addition to the contribution of cancer cells, the solid tumor microenvironment (TME) has a
critical role in determining tumor expansion, antitumor immunity, and the response to …

Medicinal chemical approaches have been applied to all four of the adenosine receptor
(AR) subtypes (A1, A2A, A2B, and A3) to create selective agonists and antagonists for each …

The adenosine A2A receptor is a G-protein-coupled receptor (GPCR) that has been
extensively studied during the past few decades because it offers numerous possibilities for …

No drug has been approved to prevent neuronal cell loss in patients suffering from
Parkinson's disease (PD) or Alzheimer's disease (AD); despite increased comprehension of …