BMAL1 is a core component of the circadian clock loop, which directs the sophisticated
circadian expression of clock-controlled genes. Skeletal Bone development is a complex …

The circadian clock modulates almost all vital aspects of our physiology and metabolism,
including processes relevant to dentistry, such as healing, inflammation and nociception …

The purpose of this study was to evaluate the effects of a light continuous force and an
interrupted force with weekly reactivation on interleukin-1β (IL-1β) and prostaglandin E2 …

Periodontal ligament tissue is remodeled on both the tension and compression sides of
moving teeth during orthodontic tooth movement. The present study was designed to clarify …

Orthodontic tooth movement progresses by a combination of periodontal ligament (PDL)
tissue and alveolar bone remodeling processes. Besides the remodeling of alveolar bone …

The purpose of this study was to investigate whether there are any differences in tooth
movement or in the response of periodontal tissue to orthodontic force when the force is …

Inbred strains of mice are increasingly being used as an animal model to investigate skeletal
disorders relevant to humans. In the bone field, one of the most convenient endpoints for …

Background An orthodontic device that moves teeth with pulsating force was invented and
underwent a single center, controlled, clinical trial to test its safety and efficacy for treatment …

The human body displays central circadian rhythms of activity. Recent findings suggest that
peripheral tissues, such as bone, possess their own circadian clocks. Studies have shown …

We previously reported that the wearing of cervical headgear induced forward displacement
of the mandible in awake subjects. However, it was unclear whether such mandibular …