Diabetic Nephropathy (DN) is believed to be a major microvascular complication of
diabetes. The hallmark of DN includes deposition of Extracellular Matrix (ECM) proteins …

In a variety of normal and pathological cell types, Rho-kinases I and II (ROCKI/II) play a
pivotal role in the organization of the nonmuscle and smooth muscle cytoskeleton and …

Purpose.: To investigate the effect of K-115, a novel Rho kinase (ROCK) inhibitor, on retinal
ganglion cell (RGC) survival in an optic nerve crush (NC) model. Additionally, to determine …

A Rho-associated coiled-coil kinase (ROCK) is identified as a critical downstream effector of
GTPase RhoA which contains two isoforms, ROCK1 (also known as p160ROCK and ROKβ) …

Gastric cancer is one of the most frequent and lethal malignancies worldwide because of
high frequency of metastasis. Tumor cell motility and invasion play fundamental roles in …

Injury to the podocyte results in proteinuria and often leads to progressive kidney disease.
As podocytes have limited ability to repair and/or regenerate, the extent of podocyte injury is …

Cancer-associated changes in cellular behavior, such as modified cell-cell contact,
increased migratory potential, and generation of cellular force, all require alteration of the …

Rho-family GTPases like RhoA and Rac-1 are potent regulators of cellular signaling that
control gene expression, migration and inflammation. Activation of Rho-GTPases has been …

Emerging evidence has shown that microRNAs (miRNAs) play a mediatory role in the
pathogenesis of diabetic nephropathy (DN), but the function of the involved miRNAs is still …

Objectives Diabetic encephalopathy (DE) is a serious complication of diabetes mainly
occurring in the elderly patients. Berberine (BBR) is an isoquinoline alkaloids extracted from …