Osteocytes, former osteoblasts encapsulated by mineralized bone matrix, are far from being
passive and metabolically inactive bone cells. Instead, osteocytes are multifunctional and …

After discovering that lack of Sost/sclerostin expression is the cause of the high bone mass
human syndromes Van Buchem disease and sclerosteosis, extensive animal …

Epigenetics describes mechanisms which control gene expression and cellular processes
without changing the DNA sequence. The main mechanisms in epigenetics are DNA …

Osteoporosis is a multifactorial disease in which genetic factors and epigenetic
modifications play a major role. DNA methylation is known for gene silencing and its effect …

Giant cell tumor is a relatively uncommon but painful tumor of bone, which can metastasize
to the lungs. The RANK pathway is often reported to be involved in the pathogenesis of giant …

Bone diseases such as osteoarthritis, osteoporosis, and bone tumor present a severe public
health problem. Osteogenic differentiation is a complex process associated with the …

EN1 encodes a homeodomain-containing transcription factor and is a determinant of bone
density and fracture. Previous powerful genome-wide association studies (GWASs) have …

Poor intrauterine and childhood growth has been linked with the risk of osteoporosis in later
life, a relationship that may in part be mediated through altered epigenetic regulation of …

Обсуждаются перспективы использования эпигенетических механизмов регуляции
остеобластои остеокластогенеза в ранней диагностике и лечении остеопороза …

Introduction Although there is a documented social gradient for osteoporosis, the underlying
mechanism (s) for that gradient remain unknown. We propose a conceptual model based …