Role of Glial Cells in Neuronal Function, Mood Disorders, and Drug Addiction
Y Tizabi, B Getachew, SR Hauser, V Tsytsarev… - Brain Sciences, 2024 - mdpi.com
Mood disorders and substance use disorder (SUD) are of immense medical and social
concern. Although significant progress on neuronal involvement in mood and reward …
concern. Although significant progress on neuronal involvement in mood and reward …
Focal mu‐opioid receptor activation promotes neuroinflammation and microglial activation in the mesocorticolimbic system: Alterations induced by inflammatory pain
J Cuitavi, P Andrés‐Herrera, D Meseguer… - Glia, 2023 - Wiley Online Library
Microglia participates in the modulation of pain signaling. The activation of microglia is
suggested to play an important role in affective disorders that are related to a dysfunction of …
suggested to play an important role in affective disorders that are related to a dysfunction of …
[HTML][HTML] Natural products as the therapeutic strategies for addiction
R Yu, DL Kong, C Liao, YJ Yu, ZW He… - Biomedicine & …, 2024 - Elsevier
Abstract World Drug Report 2023 concluded that 296 million people abused drugs, 39.5
million became addiction and 494,000 died as a direct or indirect result of addiction …
million became addiction and 494,000 died as a direct or indirect result of addiction …
[HTML][HTML] A natural small molecule aspidosperma-type alkaloid, hecubine, as a new TREM2 activator for alleviating lipopolysaccharide-induced neuroinflammation in …
L Li, YL He, N Xu, XF Wang, B Song, BQ Tang… - Redox Biology, 2024 - Elsevier
Neuroinflammation and oxidative stress play a crucial role in the pathogenesis of
neurodegenerative diseases, including Alzheimer's disease. The triggering receptor …
neurodegenerative diseases, including Alzheimer's disease. The triggering receptor …
Supraspinal neuroinflammation and anxio-depressive-like behaviors in young-and older-adult mice with osteoarthritis pain: the effect of morphine
G Amodeo, S Franchi, S D'Agnelli, G Galimberti… - …, 2023 - Springer
Rationale Asteoarthritis (OA) is a leading cause of chronic pain in the elderly population and
is often associated with emotional comorbidities such as anxiety and depression. Despite …
is often associated with emotional comorbidities such as anxiety and depression. Despite …
Zingerone alleviates morphine tolerance and dependence in mice by reducing oxidative stress-mediated NLRP3 inflammasome activation
S Molavinia, M Nikravesh, M Pashmforoosh… - Neurochemical …, 2024 - Springer
Morphine (MPH) is widely used for pain management; however, long-term MPH therapy
results in antinociceptive tolerance and physical dependence, limiting its clinical use …
results in antinociceptive tolerance and physical dependence, limiting its clinical use …
[HTML][HTML] A synthetic peptide exerts nontolerance-forming antihyperalgesic and antidepressant effects in mice
Y Wu, X Song, YZ Ji, G Chen, L Zhao - Neurotherapeutics, 2024 - Elsevier
Chronic pain is a prevalent and persistent ailment that affects individuals worldwide.
Conventional medications employed in the treatment of chronic pain typically demonstrate …
Conventional medications employed in the treatment of chronic pain typically demonstrate …
Synthesis, In Silico Logp Study, and In Vivo Analgesic Activity of Analogs of Tetrapeptide FELL
B Borisova, H Nocheva, S Gérard, M Laronze-Cochard… - Pharmaceuticals, 2023 - mdpi.com
Background: The inflammatory process represents a specific response of the organism's
immune system. More often, it is related to the rising pain in the affected area. Independently …
immune system. More often, it is related to the rising pain in the affected area. Independently …
Dermorphin [D-Arg2, Lys4](1-4) Amide Alleviates Frostbite-Induced Pain by Regulating TRP Channel-Mediated Microglial Activation and Neuroinflammation
Cold injury or frostbite is a common medical condition that causes serious clinical
complications including sensory abnormalities and chronic pain ultimately affecting overall …
complications including sensory abnormalities and chronic pain ultimately affecting overall …