B cells are central to the pathogenesis of multiple autoimmune diseases, through antigen
presentation, cytokine secretion, and the production of autoantibodies. During development …

Energy metabolism maintains the activation of intracellular and intercellular signal
transduction, and plays a crucial role in immune response. Under environmental stimulation …

В спектре механизмов хронического воспаления центральное место занимают два
фундаментальных патологических процесса-аутоиммунитет и аутовоспаление …

In the last two decades,“Immunometabolism” has emerged as a continuously increasing
area of research with significant impact on biomedicine [1, 2]. The term immunometabolism …

Although metabolic reprogramming during the differentiation of regulatory T cells (Treg cells)
has been extensively studied, the molecular switch to alter energy metabolism remains …

Aberrant metabolic demand is observed in immune/inflammatory disorders, yet the role in
pathogenesis remains unclear. Here, we discover that in lupus, activated B cells, including …

Simple Summary Fibroblasts are critical regulators of several physiological processes linked
to extracellular matrix regulation. Under certain conditions, fibroblasts can also transform …

Objective Although Leflunomide (LEF) is effective in treating rheumatoid arthritis (RA), there
are still a considerable number of patients who respond poorly to LEF treatment. Till date …

The molecular mechanisms that govern differential T cell development from CD4+ CD25-
conventional T (Tconv) into CD4+ CD25+ forkhead-box-P3+ (FoxP3+) inducible regulatory T …

Background Abnormal intracellular glucose/fatty acid metabolism of T cells has tremendous
effects on their immuno-modulatory function, which is related to the pathogenesis of …