Background This study was undertaken to determine whether use of the direct renin inhibitor
aliskiren would reduce cardiovascular and renal events in patients with type 2 diabetes and …

The cardiovascular disease continuum begins with risk factors such as diabetes mellitus
(DM), progresses to vasculopathy and myocardial dysfunction, and finally ends with …

The ACC, the AHA, and the Heart Failure Society of America (HFSA) recognize that the
introduction of effective new therapies that potentially affect a large number of patients …

Objective To assess the effect of antihypertensive treatment on mortality and cardiovascular
morbidity in people with diabetes mellitus, at different blood pressure levels. Design …

Level of evidence Level A Data obtained from multiple concordant large randomized trials
and/or robust meta-analysis of randomized clinical trials Level B Data obtained from less …

Oxidative stress, defined as an excess production of reactive oxygen species (ROS) relative
to antioxidant defense, has been shown to play an important role in the pathophysiology of …

An initiation-promotion protocol was used to test the hypothesis that unleaded gasoline (UG)
vapor acts as a liver tumor promoter in female mice under exposure conditions in which UG …

(AHA) scientific statement “Treatment of Hypertension in the Prevention and Management of
Ischemic Heart Disease: A Scientific Statement From the American Heart Association …

After its discovery in the early 1980s, the natriuretic peptide (NP) system has been
extensively characterized and its potential influence in the development and progression of …

The prevalence of patients with concomitant heart failure (HF) and diabetes mellitus (DM)
continues to increase with the general aging of the population. In patients with chronic HF …