Background It is not known whether drugs that block the renin–angiotensin system reduce
the risk of diabetes and cardiovascular events in patients with impaired glucose tolerance …

Guidelines and Expert Consensus Documents produced by Task Forces, expert groups, or
consensus panels. The chosen experts in these writing panels are asked to provide …

This article provides a contemporary review and a new perspective on the role of neprilysin
inhibition in heart failure (HF) in the context of recent clinical trials and addresses potential …

Heart failure due to nonischemic dilated cardiomyopathy (DCM) contributes significantly to
the global burden of cardiovascular disease. Myocarditis is, in turn, a major cause of acute …

A 74-year-old man with a history of hypertension and myocardial infarction that had occurred
in the remote past presents with breathlessness on exertion. On examination, his pulse is 76 …

Objective To examine the association between antihypertensive treatment and specific
adverse events. Design Systematic review and meta-analysis. Eligibility criteria Randomised …

Objectives: The purpose of this study was to quantitatively assess the relationship between
therapy-induced changes in left ventricular (LV) remodeling and longer-term outcomes in …

resultant striking increase in morbidity and mortality. The transition to symptomatic heart
failure is accompanied by further activation of neurohormonal and cytokine systems, as well …

BACKGROUND: The prevalence of renal dysfunction in patients hospitalized with acute
decompensated heart failure remains poorly characterized. METHODS AND RESULTS …

Hypertension is a frequent, chronic, age-related disorder, which often entails debilitating
cardiovascular and renal complications. Blood pressure is usually noted in combination with …