Objective Caffeine, a non‐selective adenosine receptor (AR) antagonist, is the most
consumed psychostimulant in the world. Caffeine has been suggested to regulate …

Interactions between subtypes of dopamine, glutamate and adenosine receptors seem to
play an important integrative role in the function of striatal gamma-aminobutyric acid (GABA) …

Adenosine is a naturally occurring nucleoside present ubiquitously throughout the body as a
metabolic intermediate. Besides its metabolic role within the cells, adenosine is released …

Dopaminergic and glutamatergic neurotransmissions in the striatum play an essential role in
motor-and reward-related behaviors. Dysfunction of these neurotransmitter systems has …

Over the past decade there has been a revolution in the field of G protein-coupled receptor
(GPCR) structural biology. Many years of innovative research from different areas have …

Human adenosine A2A and rat dopamine D2 receptors (A2A and D2 receptors) were co-
transfected in Chinese hamster ovary (CHO) cells to study the interactions between two …

Evidence for a role of dopaminergic neurotransmission in the motor effects of adenosine
antagonists, such as caffeine, is reviewed, based on the existence of specific antagonistic …

PEP-19 is a neuronal calmodulin-binding protein, and as such, a putative modulator of
calcium regulated processes. In the present study, we used proteomics technology …

Adenosine exerts its effects through four subtypes of G‐protein‐coupled receptors (GPCRs):
adenosine A1 and A3 receptors (A3R), which generally couple to Gi proteins and adenosine …

This brief review presents a personal perspective on the historical development of the
current knowledge about the biologically important concept of functional antagonism …