Collagens serve essential mechanical functions throughout the body, particularly in the
connective tissues. In articular cartilage, collagens provide most of the biomechanical …

Osteoarthritis (OA), a common cause of chronic articular cartilage degeneration, is the main
cause of disability in older adults and severely affects quality of life. Multiple factors are …

The synovial tissues under rheumatoid arthritis conditions are usually infiltrated by
inflammatory cells, particularly M1 macrophages with aberrant redox homeostasis, which …

Background Osteoarthritis (OA) is a degenerative disease closely related to aging.
Nevertheless, the role and mechanisms of aging in osteoarthritis remain unclear. This study …

Osteoarthritis (OA) is one of the most prevalent musculoskeletal disorders globally, and
treating OA remains a significant challenge. Currently, pharmacological treatments primarily …

As society ages, the number of patients with spinal degenerative diseases (SDD) is
increasing, posing a major socioeconomic problem for patients and their families. SDD …

The strong interest shown in the study of the causes of aging in recent decades has
uncovered many mechanisms that could contribute to the rate of aging. These include …

Different from inflammatory arthritis, where biologicals and targeted synthetic molecules
have revolutionized the disease course, no drug has demonstrated a disease modifying …

Ferroptosis is involved in the pathogenesis of osteoarthritis (OA) while suppression of
chondrocyte ferroptosis has a beneficial effect on OA. However, the molecular mechanism of …

This study aims to determine the molecular mechanisms and analgesic effects of transient
receptor potential vanilloid 1 (TRPV1) in the treatments of osteoarthritis (OA) and rheumatoid …