Anti-Inflammatory Activity of APPA (Apocynin and Paeonol) in Human Articular Chondrocytes

M Fernández-Moreno, T Hermida-Gómez, N Larkins… - Pharmaceuticals, 2024 - mdpi.com
Osteoarthritis (OA) is a chronic joint disease leading to cartilage loss and reduction in the
joint space which results in pain. The current pharmacological treatment of OA is inadequate …

Effects of Space Dimensionality within Scaffold for Bone Regeneration with Large and Oriented Blood Vessels

K Hayashi, R Kishida, A Tsuchiya, K Ishikawa - Materials, 2023 - mdpi.com
The internal structure of the scaffolds is a key factor for bone regeneration. In this study, we
focused on the space dimensionality within the scaffold that may control cell migration and …

Enhanced Surface Immunomodification of Engineered Hydrogel Materials through Chondrocyte Modulation for the Treatment of Osteoarthritis

J Yao, Z Huo, J Xu, J Shang, Y Weng, D Xu, T Liu… - Coatings, 2024 - mdpi.com
Osteoarthritis (OA) is characterized by cartilage degeneration and synovial inflammation,
with chondrocytes playing a pivotal role in this disease. However, inflammatory mediators …

Three‐dimensional printed biomimetic multilayer scaffolds coordinated with sleep‐related small extracellular vesicles: A strategy for extracellular matrix homeostasis …

XR Li, QS Deng, PL Liu, SH He, Y Gao, ZY Wei… - View, 2024 - Wiley Online Library
Cartilage defects resulting from injury or degeneration are a common clinical problem, and
due to its avascular nature, articular cartilage has poor self‐healing capacity. Three …

Studies on blocking the JAK2/STAT3 signaling pathway with elastin peptides from skipjack tuna (Katsuwonus pelamis) bulbus cordis to alleviate osteoarthritis

Q Wu, B Liu, R Yu, X Sun, Z Wang, J Zhou, C Lu… - Food Bioscience, 2023 - Elsevier
Osteoarthritis (OA) is a chronic disease associated with bone and muscle degeneration that
causes great disturbances to daily lives. Skipjack tuna elastin peptides (STEP) is a kind of …

Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of Radix Rehmanniae Praeparata-Angelica Sinensis-Radix …

L Liu, B Zhang, Z Zhou, J Yang, A Li, Y Wu… - Drug Design …, 2024 - Taylor & Francis
Background Knee osteoarthritis (KOA) is a persistent degenerative condition characterized
by the deterioration of cartilage. The Chinese herbal formula Radix Rehmanniae Praeparata …

Tanshinone IIA Facilitates Efficient Cartilage Regeneration under Inflammatory Factors Caused Stress via Upregulating LncRNA NEAT1_2

J Sun, W Chen, Z Zhou, X Chen, Y Zuo, J He, H Liu - Biomedicines, 2023 - mdpi.com
(1) Background: Osteoarthritis (OA) is a crippling condition characterized by chondrocyte
dedifferentiation, cartilage degradation, and subsequent cartilage defects. Unfortunately …

Osteoclasts and osteoarthritis: Novel intervention targets and therapeutic potentials during aging

H Wang, T Yuan, Y Wang, C Liu, D Li, Z Li, S Sun - Aging Cell, 2024 - Wiley Online Library
Osteoarthritis (OA), a chronic degenerative joint disease, is highly prevalent among the
aging population, and often leads to joint pain, disability, and a diminished quality of life …

[HTML][HTML] Lei's formula attenuates osteoarthritis mediated by suppression of chondrocyte senescence via the mTOR axis: in vitro and in vivo experiments

X Zhou, WK Li, C Zhuang, XC Zhou, XF Zhao… - Aging (Albany …, 2024 - ncbi.nlm.nih.gov
Abstract Lei's formula (LSF), a traditional Chinese herbal remedy, is recognized for its
remarkable clinical effectiveness in treating osteoarthritis (OA). Despite its therapeutic …

[PDF][PDF] The Emerging Role of the Mitochondrial Respiratory Chain in Skeletal Aging

H Tao, P Zhu, W Xia, M Chu, K Chen, Q Wang… - Aging and …, 2023 - researchgate.net
Maintenance of mitochondrial homeostasis is crucial for ensuring healthy mitochondria and
normal cellular function. This process is primarily responsible for regulating processes that …