Primary sclerosing cholangitis (PSC) represents a chronic cholestatic liver disease with
fibroobliterative sclerosis of intra-and/or extrahepatic bile ducts, eventually leading to biliary …

There are trillions of microbes residing in our body, with their collective genomes much more
than human genomes. They have been living in a close relationship with us and play a role …

Background Ulcerative colitis is a heterogeneous disease in terms of disease course,
location, and therapeutic response. The current study was done to assess the alteration of …

AIM: To evaluate ATP-binding cassette (ABC) transporters in colonic pathophysiology as
they had recently been related to colorectal cancer (CRC) development. METHODS …

The efficacy and safety of pharmacotherapies are determined by the complex processes
involved in the interactions between drugs with the human body, including pharmacokinetic …

Background Inflammatory bowel disease (IBD) is a chronic disease of unknown etiology in
which genetic factors contribute to development of disease. Single nucleotide …

Objective The cornerstone of conventional treatment for inflammatory bowel disease (IBD) is
glucocorticoid (GC). Single nucleotide polymorphisms (SNPs) of genes such as multidrug …

The farnesoid X receptor (FXR) is implicated in Crohn's disease (CD) pathogenesis. It is
unclear how genetic variation in FXR impacts CD severity versus genetic variation in nuclear …

Individual differences in IBD illness severity, behavior, progression, and therapy response
are evident. Since a break in the intestinal epithelial barrier causes IBD to begin, mucosal …

AIM: To evaluate the correlations between cytotoxic T lymphocyte-associated antigen-4
(CTLA-4) and multi-drug resistance 1 (MDR1) genes polymorphisms with ulcerative colitis …