Hippocampal contributions to social and cognitive deficits in autism spectrum disorder

SM Banker, X Gu, D Schiller, JH Foss-Feig - Trends in neurosciences, 2021 - cell.com
Autism spectrum disorder (ASD) is characterized by hallmark impairments in social
functioning. Nevertheless, nonsocial cognition, including hippocampus-dependent spatial …

[HTML][HTML] Male sex bias in early and late onset neurodevelopmental disorders: Shared aspects and differences in Autism Spectrum Disorder, Attention Deficit …

S Santos, H Ferreira, J Martins, J Goncalves… - Neuroscience & …, 2022 - Elsevier
Neurodevelopmental disorders are characterized by relatively early onset, with temporal
variations across conditions. These lifelong conditions lead to social and communication …

[PDF][PDF] Establishing or exaggerating causality for the gut microbiome: lessons from human microbiota-associated rodents

J Walter, AM Armet, BB Finlay, F Shanahan - Cell, 2020 - cell.com
Human diseases are increasingly linked with an altered or" dysbiotic" gut microbiota, but
whether such changes are causal, consequential, or bystanders to disease is, for the most …

Brain disorders? Not really: Why network structures block reductionism in psychopathology research

D Borsboom, AOJ Cramer, A Kalis - Behavioral and Brain Sciences, 2019 - cambridge.org
In the past decades, reductionism has dominated both research directions and funding
policies in clinical psychology and psychiatry. The intense search for the biological basis of …

[PDF][PDF] Dissecting the contribution of host genetics and the microbiome in complex behaviors

SA Buffington, SW Dooling, M Sgritta, C Noecker… - Cell, 2021 - cell.com
The core symptoms of many neurological disorders have traditionally been thought to be
caused by genetic variants affecting brain development and function. However, the gut …

A dopamine hypothesis of autism spectrum disorder

D Pavăl - Developmental neuroscience, 2017 - karger.com
Autism spectrum disorder (ASD) comprises a group of neurodevelopmental disorders
characterized by social deficits and stereotyped behaviors. While several theories have …

[HTML][HTML] Current enlightenment about etiology and pharmacological treatment of autism spectrum disorder

N Eissa, M Al-Houqani, A Sadeq, SK Ojha… - Frontiers in …, 2018 - frontiersin.org
Autistic Spectrum Disorder (ASD) is a complex neurodevelopmental brain disorder
characterized by two core behavioral symptoms, namely impairments in social …

Beyond the three-chamber test: toward a multimodal and objective assessment of social behavior in rodents

R Jabarin, S Netser, S Wagner - Molecular Autism, 2022 - Springer
Main In recent years, substantial advances in social neuroscience have been realized,
including the generation of numerous rodent models of autism spectrum disorder. Still, it can …

Behavioral tests assessing neuropsychiatric phenotypes in adolescent mice reveal strain-and sex-specific effects

A Eltokhi, B Kurpiers, C Pitzer - Scientific reports, 2020 - nature.com
In humans, infancy and adolescence are associated with major changes in synaptic
functions and ongoing maturation of neural networks, which underlie the major behavioral …

[HTML][HTML] Neurobiology and therapeutic potential of α5-GABA type A receptors

TC Jacob - Frontiers in molecular neuroscience, 2019 - frontiersin.org
α5 subunit containing GABA type A receptors (GABAARs) have long been an enigmatic
receptor subtype of interest due to their specific brain distribution, unusual surface …