Phagocytes are key cellular participants determining important aspects of host exposure to
nanomaterials, initiating clearance, biodistribution and the tenuous balance between host …

Tuberculosis (TB) lesions are extremely complex and dynamic. Here, we review the multiple
types and fates of pulmonary lesions that form following infection by M ycobacterium …

Infections caused by antibiotic-resistant bacteria are a rising public health threat and make
the identification of new antibiotics a priority. From a cell-based screen for bactericidal …

Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a prevalent global
infectious disease and a leading cause of mortality worldwide. Currently, the only available …

Granulomas are the hallmark of Mycobacterium tuberculosis (M. tb) infection and thus sit at
the center of tuberculosis (TB) immunopathogenesis. TB can result from either early …

The development of the granuloma and its subsequent degeneration and necrosis, is the
hallmark of infection caused by Mycobacterium tuberculosis. These structures probably …

In drug development, there are typically a series of preclinical studies that must be
completed with new compounds or regimens before use in humans. A sequence of in vitro …

Persistence of Mycobacterium tuberculosis remains a significant challenge for the effective
treatment of tuberculosis in humans. In animals that develop necrotic lung lesions following …

It is set in stone that Mycobacterium tuberculosis is a facultative intracellular bacterial
parasite. This axiom drives our knowledge of the host response, the way we design vaccines …

The development of granulomatous inflammation with caseous necrosis is an important but
poorly understood manifestation of tuberculosis in humans and some animal models. In this …