Although transcatheter valve therapy is rapidly evolving, surgical valve replacement is still
required in many patients with severe left-side valve stenosis or regurgitation, the …

Prosthetic heart valve thrombosis (PVT) is a rare but serious complication with high
morbidity and mortality. The optimal treatment of the PVT is controversial and depends on …

Objectives: To investigate the efficacy and safety of initial thrombolysis by recombinant
tissue-type plasminogen activator (rt-PA) in compared with anticoagulant therapy in patients …

Valvular heart disease (VHD) is present in% 2.5% of the general US population, with
prevalence increasing to 11.7% to 13.3% in those aged> 75 years. 1 Valve-disease–related …

The patients with intermediate-high risk pulmonary embolism who have acute right
ventricular (RV) dysfunction and myocardial injury without overt hemodynamic compromise …

1.1. Methodology and Evidence Review The recommendations listed in this document are,
whenever possible, evidence based. An extensive review was conducted on literature …

Over the last two decades, thrombolytic therapy (TT) has become an alternative to surgery
as a first-line therapy in patients with thrombosed mechanical valves [1–3]. In TROIA Trial …

Objectives We compared early and long-term clinical outcomes of bioprosthetic versus
mechanical tricuspid valve replacement in a nationwide study based on the database from …

Mechanical prosthetic heart valves (MPHVs) are highly thrombogenic, and a pregnancy-
induced procoagulant status increases the risk of MPHV thrombosis. Despite numerous …

Introduction Procoagulant activity of heparanase has been recently described in several
arterial and venous thrombotic disorders. In this study, we aimed to investigate the role of …