Mass spectrometry is a central technology in the life sciences, providing our most
comprehensive account of the molecular inventory of the cell. In parallel with developments …

Biological membranes formed of amphipathic lipid bilayers provide chemical barriers to
separate cells from their external environments and define subcellular compartments …

The receptor binding and proteolysis of Spike of SARS-CoV-2 release its S2 subunit to
rearrange and catalyze viral-cell fusion. This deploys the fusion peptide for insertion into the …

Over the past decade, the vast amount of information generated through structural and
biophysical studies of GPCRs has provided unprecedented mechanistic insight into the …

Lipid-bilayer nanodiscs provide a stable, native-like membrane environment for the
functional and structural studies of membrane proteins and other membrane-binding …

The nanodisc technology is increasingly used for structural studies on membrane proteins
and drug delivery. The development of synthetic polymer nanodiscs and the recent …

CENTAUR has been selected as one of the eight initial instruments to be built at the Second
Target Station (STS) of the Spallation Neutron Source at Oak Ridge National Laboratory. It is …

Cholesterol has been conjectured to be a modulator of the amyloid cascade, the mechanism
that produces the amyloid-β (Aβ) peptides implicated in the onset of Alzheimer's disease …

Peripheral myelin protein (PMP22) is an integral membrane protein that traffics inefficiently
even in wild-type (WT) form, with only 20% of the WT protein reaching its final plasma …

Native ion mobility-mass spectrometry (IM-MS) has emerged as an information-rich
technique for gas phase protein structure characterization; however, IM resolution is …