m6A methylation in cardiovascular diseases: from mechanisms to therapeutic potential

L Li, N Xu, J Liu, Z Chen, X Liu, J Wang - Frontiers in genetics, 2022 - frontiersin.org
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide.
Recent studies have shown that n6-methyladenosine (m6A) plays a major role in …

The potential role of m6A RNA methylation in the aging process and aging-associated diseases

J Sun, B Cheng, Y Su, M Li, S Ma, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
N6-methyladenosine (m6A) is the most common and conserved internal eukaryotic mRNA
modification. m6A modification is a dynamic and reversible post-transcriptional regulatory …

N6-Methyladenosine methyltransferase METTL3 promotes angiogenesis and atherosclerosis by upregulating the JAK2/STAT3 pathway via m6A reader IGF2BP1

G Dong, J Yu, G Shan, L Su, N Yu… - Frontiers in cell and …, 2021 - frontiersin.org
Atherosclerosis (AS) is a life-threatening vascular disease. RNA N6-methyladenosine (m6A)
modification level is dysregulated in multiple pathophysiologic processes including AS. In …

FTO alleviates cerebral ischemia/reperfusion-induced neuroinflammation by decreasing cGAS mRNA stability in an m6A-dependent manner

Z Yu, L Zheng, Y Geng, Y Zhang, Y Wang, G You… - Cellular signalling, 2023 - Elsevier
Microglia-mediated inflammation is a major contributor to the brain damage in cerebral
ischemia and reperfusion (I/R) injury, and N6-Methyladenosine (m6A) has been implicated …

RNA modification m6Am: the role in cardiac biology

D Benak, F Kolar, L Zhang, Y Devaux, M Hlavackova - Epigenetics, 2023 - Taylor & Francis
Epitranscriptomic modifications have recently emerged into the spotlight of researchers due
to their vast regulatory effects on gene expression and thereby cellular physiology and …

29 m6A‐RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation – 102 …

M Liu, K Xu, F Saaoud, Y Shao, R Zhang… - Journal of …, 2022 - Wiley Online Library
We performed a database mining on 102 transcriptomic datasets for the expressions of 29
m6A‐RNA methylation (epitranscriptomic) regulators (m6A‐RMRs) in 41 diseases and …

Silencing METTL3 stabilizes atherosclerotic plaques by regulating the phenotypic transformation of vascular smooth muscle cells via the miR-375-3p/PDK1 axis

J Chen, K Lai, X Yong, H Yin, Z Chen, H Wang… - … drugs and therapy, 2023 - Springer
Purpose Atherosclerosis (AS) is a primary cause of cardiovascular diseases. This study
investigated the mechanism of methyltransferase-like 3 (METTL3) in AS plaques via …

Emerging role of epitranscriptomics in diabetes mellitus and its complications

X Geng, Z Li, Y Yang - Frontiers in endocrinology, 2022 - frontiersin.org
Diabetes mellitus (DM) and its related complications are among the leading causes of
disability and mortality worldwide. Substantial studies have explored epigenetic regulation …

[HTML][HTML] m6A methyltransferase METTL3 participated in sympathetic neural remodeling post-MI via the TRAF6/NF-κB pathway and ROS production

L Qi, Y Wang, H Hu, P Li, H Hu, Y Li, K Wang… - Journal of Molecular and …, 2022 - Elsevier
Objective Sudden cardiac death caused by ventricular arrhythmias (VAs) is the main cause
of high mortality in patients with myocardial infarction (MI). Sympathetic neural remodeling …

N-6-Methyladenosine in vasoactive microRNAs during hypoxia; a novel role for METTL4

DAL van den Homberg, RVCT van der Kwast… - International journal of …, 2022 - mdpi.com
N-6-methyladenosine (m6A) is the most prevalent post-transcriptional RNA modification in
eukaryotic cells. The modification is reversible and can be dynamically regulated by writer …