Immune microenvironment and immunotherapeutic management in virus-associated digestive system tumors

P Sarantis, EM Trifylli, E Koustas… - International Journal of …, 2022 - mdpi.com
The development of cancer is a multifactorial phenomenon, while it constitutes a major
global health problem. Viruses are an important factor that is involved in tumorigenesis and …

What role does PDL1 play in EMT changes in tumors and fibrosis?

YC Zhang, YT Zhang, Y Wang, Y Zhao… - Frontiers in …, 2023 - frontiersin.org
Epithelial-mesenchymal transformation (EMT) plays a pivotal role in embryonic
development, tissue fibrosis, repair, and tumor invasiveness. Emerging studies have …

Contemporary Insights into Hepatitis C Virus: A Comprehensive Review

M Sallam, R Khalil - Microorganisms, 2024 - mdpi.com
Hepatitis C virus (HCV) remains a significant global health challenge. Approximately 50
million people were living with chronic hepatitis C based on the World Health Organization …

Hepatocyte-derived FGL1 accelerates liver metastasis and tumor growth by inhibiting CD8+ T and NK cells

F Xi, H Sun, H Peng, Z Lian, H Wei, Z Tian, R Sun… - JCI insight, 2024 - insight.jci.org
Fibrinogen-like protein 1 (FGL1) contributes to the proliferation and metabolism of
hepatocytes; however, as a major ligand of the immune checkpoint, its role in the liver …

Immune microenvironment changes of liver cirrhosis: emerging role of mesenchymal stromal cells

Q Yi, J Yang, Y Wu, Y Wang, Q Cao… - Frontiers in Immunology, 2023 - frontiersin.org
Cirrhosis is a progressive and diffuse liver disease characterized by liver tissue fibrosis and
impaired liver function. This condition is brought about by several factors, including chronic …

[HTML][HTML] Hepatitis C virus and hepatocellular carcinoma: carcinogenesis in the era of direct-acting antivirals

F Fiehn, C Beisel, M Binder - Current Opinion in Virology, 2024 - Elsevier
Chronic hepatitis C virus (HCV) infection is a major cause of hepatic fibrosis and cirrhosis,
with a risk for the development of hepatocellular carcinoma (HCC). Although highly effective …

The Novel Action of miR‐193b‐3p/CDK1 Signaling in HCC Proliferation and Migration: A Study Based on Bioinformatic Analysis and Experimental Investigation

X Pang, W Wan, X Wu, Y Shen - International Journal of …, 2022 - Wiley Online Library
Hepatocellular carcinoma (HCC) is a common human malignancy with high mortality and
dismal prognosis. A growing number of novel targets underlying HCC pathophysiology have …

[HTML][HTML] Predictive plasma biomarkers of long-term increase in hepatic steatosis index after HCV eradication in HIV/HCV-coinfected patients

R Martín-Escolano, A Virseda-Berdices… - Biomedicine & …, 2023 - Elsevier
Hepatic steatosis is a common condition found in the liver of hepatitis C virus (HCV)-infected
patients, contributing to more severe forms of liver disease. In addition, the human …

[HTML][HTML] Molecular mechanisms underlying SARS-CoV-2 hepatotropism and liver damage

J Quarleri, MV Delpino - World Journal of Hepatology, 2024 - ncbi.nlm.nih.gov
Abstract In coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2) primarily targets the respiratory system, but evidence suggests …

Hepatitis C virus infection in patients undergoing surgery in a single tertiary academic center

JS Lee, HW Lee, MN Kim, BK Kim… - Journal of …, 2024 - Wiley Online Library
Abstract Background and Aim Lack of awareness disturbs proper care for hepatitis C virus
(HCV) infections in patients undergoing surgery. We investigated the status of HCV …