Protein kinases constitute one of the largest protein families in humans. 1, 2 The kinase
enzymes in this family catalyze phosphorylation of serine, threonine, or tyrosine residues …

ABSTRACT H89 is marketed as a selective and potent inhibitor of protein kinase A (PKA).
Since its discovery, it has been used extensively for evaluation of the role of PKA in the …

Hematopoietic progenitor kinase 1 (HPK1), a hematopoietic cell-restricted member of the
serine/threonine Ste20-related protein kinases, is a negative regulator of the T cell receptor …

Pim-1 kinase is a member of a distinct class of serine/threonine kinases consisting of Pim-1,
Pim-2, and Pim-3. Pim kinases are highly homologous to one another and share a unique …

Protein kinase inhibitors are a well-established class of clinically useful drugs, particularly
for the treatment of cancer. Achieving inhibitor selectivity for particular protein kinases often …

The Trk family of neurotrophin receptors, which includes the three highly homologous
proteins TrkA, TrkB and TrkC, is strongly associated with central and peripheral nervous …

The c-Jun N-terminal kinases (JNK-1,-2, and-3) are members of the mitogen activated
protein (MAP) kinase family of enzymes. They are activated in response to certain cytokines …

Among the aromatic heterocycle rings, pyrazole–a five-membered ring with two adjacent
nitrogen atoms in its structure has been postulated as a potent candidate in the …

The use of kinase-directed precision medicine has been heavily pursued since the
discovery and development of imatinib. Annually, it is estimated that around∼ 20 000 new …

Abstract A novel series of 2-(3, 6-dimethyl-1-phenyl-1H-pyrazolo [3, 4-d] pyrimidin-4-yloxy)-
N-(4-substitutedbenzylidene) acetohydrazide (12a–g) was prepared and their structures …