Extracellular nucleotides (eg, ATP, ADP, UTP, UDP) released by inflammatory cells interact
with specific purinergic P2 type receptors to modulate their recruitment and activation. The …

Extracellular nucleotides, mainly ATP, but also ADP, UTP, UDP and UDP-sugars,
adenosine, and adenine base participate in the “purinergic signalling” pathway, an …

The connexin family of channel-forming proteins is present in every tissue type in the human
anatomy. Connexins are best known for forming clustered intercellular channels, structurally …

Aims Sodium-glucose cotransporter 2 inhibitors have beneficial effects on heart failure and
cardiovascular mortality in diabetic and non-diabetic patients, with unclear mechanisms …

Communication is important to ensure the correct and efficient flow of information, which is
required to sustain active social networks. A fine-tuned communication between cells is vital …

Gap junctions consist of arrays of intercellular channels that enable adjacent cells to
communicate both electrically and metabolically. Gap junctions have a wide diversity of …

Normal cardiac function requires that intracellular Ca2+ concentration be reduced to low
levels in diastole so that the ventricle can relax and refill with blood. Heart failure is often …

Cx43, a major cardiac connexin, forms precursor hemichannels that accrue at the
intercalated disc to assemble as gap junctions. While gap junctions are crucial for electrical …

Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate
direct intercellular communication, a critical feature for the development, function, and …

The heart works as a functional syncytium, which is realized via cell-cell coupling
maintained by gap junction channels. These channels connect two adjacent cells, so that …