The molecular principles of gene regulation by Polycomb repressive complexes

NP Blackledge, RJ Klose - Nature reviews Molecular cell biology, 2021 - nature.com
Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …

Regulation, functions and transmission of bivalent chromatin during mammalian development

TA Macrae, J Fothergill-Robinson… - … reviews Molecular cell …, 2023 - nature.com
Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

Understanding plant stress memory response for abiotic stress resilience: Molecular insights and prospects

M Sharma, P Kumar, V Verma, R Sharma… - Plant Physiology and …, 2022 - Elsevier
As sessile species and without the possibility of escape, plants constantly face numerous
environmental stresses. To adapt in the external environmental cues, plants adjust …

COMPASS and SWI/SNF complexes in development and disease

BK Cenik, A Shilatifard - Nature Reviews Genetics, 2021 - nature.com
Abstract The Trithorax group (TrxG) of proteins is a large family of epigenetic regulators that
form multiprotein complexes to counteract repressive developmental gene expression …

[HTML][HTML] An evolutionarily conserved function of polycomb silences the MHC class I antigen presentation pathway and enables immune evasion in cancer

ML Burr, CE Sparbier, KL Chan, YC Chan… - Cancer cell, 2019 - cell.com
Loss of MHC class I (MHC-I) antigen presentation in cancer cells can elicit immunotherapy
resistance. A genome-wide CRISPR/Cas9 screen identified an evolutionarily conserved …

[HTML][HTML] Adaptive sequence divergence forged new neurodevelopmental enhancers in humans

RJ Mangan, FC Alsina, F Mosti, JE Sotelo-Fonseca… - Cell, 2022 - cell.com
Searches for the genetic underpinnings of uniquely human traits have focused on human-
specific divergence in conserved genomic regions, which reflects adaptive modifications of …

[HTML][HTML] An atlas of dynamic chromatin landscapes in mouse fetal development

DU Gorkin, I Barozzi, Y Zhao, Y Zhang, H Huang… - Nature, 2020 - nature.com
Abstract The Encyclopedia of DNA Elements (ENCODE) project has established a genomic
resource for mammalian development, profiling a diverse panel of mouse tissues at 8 …

Coordinating cell proliferation and differentiation: Antagonism between cell cycle regulators and cell type-specific gene expression

S Ruijtenberg, S van den Heuvel - Cell cycle, 2016 - Taylor & Francis
Cell proliferation and differentiation show a remarkable inverse relationship. Precursor cells
continue division before acquiring a fully differentiated state, while terminal differentiation …

The transcriptional and epigenetic landscape of cancer cell lineage plasticity

A Davies, A Zoubeidi, H Beltran, LA Selth - Cancer discovery, 2023 - AACR
Lineage plasticity, a process whereby cells change their phenotype to take on a different
molecular and/or histologic identity, is a key driver of cancer progression and therapy …

Epigenetic balance of gene expression by Polycomb and COMPASS families

A Piunti, A Shilatifard - Science, 2016 - science.org
BACKGROUND Multicellular organisms depend on the precise orchestration of gene
expression to direct embryonic development and to maintain tissue homeostasis through …