A critical review on the opportunity to use placenta and innovative biomonitoring methods to characterize the prenatal chemical exposome

T Contini, R Béranger, L Multigner… - Environmental …, 2023 - ACS Publications
Adverse effects associated with chemical exposures during pregnancy include several
developmental and reproductive disorders. However, considering the tens of thousands of …

[HTML][HTML] Extracellular vesicle-mediated targeting strategies for long-term health benefits in gestational diabetes

S Nair, V Ormazabal, F Carrion, A Handberg… - Clinical …, 2023 - portlandpress.com
Extracellular vesicles (EVs) are critical mediators of cell communication, playing important
roles in regulating molecular cross-talk between different metabolic tissues and influencing …

[HTML][HTML] An integrated multi-OMICS approach highlights elevated non-esterified fatty acids impact BeWo trophoblast metabolism and lipid processing

ZJW Easton, O Sarr, L Zhao, AZ Buzatto, X Luo, S Zhao… - Metabolites, 2023 - mdpi.com
Maternal obesity and gestational diabetes mellitus (GDM) are linked with impaired placental
function and early onset of non-communicable cardiometabolic diseases in offspring …

Sex-specific impact of maternal obesity on fetal placental macrophages and cord blood triglycerides

LL Shook, KE James, DJ Roberts, CE Powe, RH Perlis… - Placenta, 2023 - Elsevier
Introduction Maternal obesity is associated with increased risk of offspring obesity and
cardiometabolic disease. Altered fetoplacental immune programming is a potential …

[HTML][HTML] Sex-dependent regulation of placental oleic acid and palmitic acid metabolism by maternal glycemia and associations with birthweight

OC Watkins, HEJ Yong, TKL Mah… - International Journal of …, 2022 - mdpi.com
Pregnancy complications such as maternal hyperglycemia increase perinatal mortality and
morbidity, but risks are higher in males than in females. We hypothesized that fetal sex …

[HTML][HTML] Dysregulation of placental lipid hydrolysis by high-fat/high-cholesterol feeding and gestational diabetes mellitus in mice

KB Kuentzel, I Bradić, ZN Mihalič, M Korbelius… - International Journal of …, 2022 - mdpi.com
Advanced maternal age and obesity are the main risk factors to develop gestational
diabetes mellitus (GDM). Obesity is a consequence of the increased storage of …

[HTML][HTML] Gestational Diabetes Mellitus and Small-for-Gestational-Age: An Insight into the Placental Molecular Biomarkers

C Giommi, M Lombό, N Montik, M Paolucci… - International Journal of …, 2023 - mdpi.com
Gestational diabetes mellitus (GDM) and small-for-gestational-age (SGA) are two metabolic-
related diseases that could affect women during pregnancy. Considering that the chorionic …

Sex differences in glycolipidic disorders after exposure to maternal hyperglycemia during early development

S Luo, H Zhu, H Huang, G Ding - Journal of Endocrinological Investigation, 2023 - Springer
Purpose The aim of this review was to summarize sex differences in glycolipid metabolic
phenotypes of human and animal models after exposure to maternal hyperglycemia and …

Fatty acids and their metabolites (resolvins) are altered in women with gestational diabetes mellitus (GDM)

N Joshi, A Jadhav, A Godhamgaonkar, D Sundrani… - Food & Function, 2024 - pubs.rsc.org
The maternal fatty acid status plays a key role in influencing pregnancy outcomes. Omega-3
fatty acids are the precursors for E-series (RvE) and D-series resolvins (RvD) and possess …

A comparative lipidomic study of the human placenta from women with or without gestational diabetes mellitus

D Jiang, J He, S Hua, J Zhang, L Liu, C Shan, X Cui… - Molecular …, 2022 - pubs.rsc.org
Gestational diabetes mellitus (GDM) is always accompanied by lipid disorders. The placenta
serves as a center for lipid synthesis and transport and plays a critical role in establishing …