Drug development for noise-induced hearing loss

I Varela-Nieto, S Murillo-Cuesta, M Calvino… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Excessive exposure to noise is a common occurrence that contributes to
approximately 50% of the non-genetic hearing loss cases. Researchers need to develop …

Review of blast noise and the auditory system

CB Paik, M Pei, JS Oghalai - Hearing research, 2022 - Elsevier
The auditory system is particularly vulnerable to blast injury due to the ear's role as a highly
sensitive pressure transducer. Over the past several decades, studies have used a variety of …

[HTML][HTML] Noise-induced cochlear synaptopathy and signal processing disorders

H Chen, L Shi, L Liu, S Yin, S Aiken, J Wang - Neuroscience, 2019 - Elsevier
Noise-induced hidden hearing loss (NIHHL) has attracted great attention in hearing
research and clinical audiology since the discovery of significant noise-induced synaptic …

Nicotinamide riboside protects noise-induced hearing loss by recovering the hair cell ribbon synapses

S Han, Z Du, K Liu, S Gong - Neuroscience Letters, 2020 - Elsevier
Objective Nicotinamide riboside (NR) has been proved to protect the hearing. To achieve
animal models of temporary threshold shift (TTS) and permanent threshold shift (PTS) …

Biomarkers for hearing dysfunction: facts and outlook

L Rüttiger, U Zimmermann, M Knipper - Orl, 2017 - karger.com
In medicine, biomarkers are a metric for disease state. More generally, a biomarker is
anything that can be used as an indicator for a particular disease state or any physiological …

Analysis of early biomarkers associated with noise-induced hearing loss among shipyard workers

Z Jiang, J Wang, Y Feng, D Sun, X Zhang… - JAMA Network …, 2021 - jamanetwork.com
Importance It is important to determine what frequencies and auditory perceptual measures
are the most sensitive early indicators of noise-induced hearing impairment. Objectives To …

[HTML][HTML] Loss of cochlear ribbon synapses in the early stage of aging causes initial hearing impairment

W Xiong, S Yu, K Liu, S Gong - American Journal of Translational …, 2020 - ncbi.nlm.nih.gov
Hearing loss can occur with aging. However, there remains debate about which cochlear
component is the most susceptible to aging insult and the consequent pathological events …

Complete Restoration of Hearing Loss and Cochlear Synaptopathy via Minimally Invasive, Single-Dose, and Controllable Middle Ear Delivery of Brain-Derived …

Q Yu, S Liu, R Guo, K Chen, Y Li, D Jiang, S Gong… - ACS …, 2024 - ACS Publications
Noise-induced hearing loss (NIHL) often accompanies cochlear synaptopathy, which can be
potentially reversed to restore hearing. However, there has been little success in achieving …

[HTML][HTML] Hearing impairment in a mouse model of diabetes is associated with mitochondrial dysfunction, synaptopathy, and activation of the intrinsic apoptosis …

AR Lyu, TH Kim, SA Shin, EH Kim, Y Yu… - International Journal of …, 2021 - mdpi.com
Although previous studies continuously report an increased risk of hearing loss in diabetes
patients, the impact of the disease on the inner ear remains unexplored. Herein, we examine …

The possibility of cochlear synaptopathy in young people using a personal listening device

N Bal, U Derinsu - Auris Nasus Larynx, 2021 - Elsevier
Objective To evaluate the association of listening to music loudly through personal listening
devices with cochlear synaptopathy in young adults. Methods Fifty healthy young adults …