Ultrasound microbubbles enhance the efficacy of insulin-like growth factor-1 therapy for the treatment of noise-induced hearing loss

YC Lin, YY Lin, HC Chen, CY Kuo, AH Liao, YL Chou… - Molecules, 2021 - mdpi.com
The application of insulin-like growth factor 1 (IGF-1) to the round window membrane (RWM)
is an emerging treatment for inner ear diseases. RWM permeability is the key factor for …

Changes in microRNA expression in the cochlear nucleus and inferior colliculus after acute noise-induced hearing loss

S Park, SH Han, BG Kim, MW Suh, JH Lee… - International Journal of …, 2020 - mdpi.com
Noise-induced hearing loss (NIHL) can lead to secondary changes that induce neural
plasticity in the central auditory pathway. These changes include decreases in the number of …

Regeneration of hair cells from endogenous otic progenitors in the adult mammalian cochlea: Understanding its origins and future directions

N Smith-Cortinez, AK Tan, RJ Stokroos… - International Journal of …, 2023 - mdpi.com
Sensorineural hearing loss is caused by damage to sensory hair cells and/or spiral ganglion
neurons. In non-mammalian species, hair cell regeneration after damage is observed, even …

Noise damage accelerates auditory aging and tinnitus: a Canadian population-based study

Z Jafari, T Copps, G Hole, BE Kolb… - Otology & …, 2020 - journals.lww.com
Objective: Age-related hearing loss (ARHL) is the third most challenging disability in older
adults. Noise is a known modifiable risk factor of ARHL, which can drive adverse health …

Speech perception in noise, gap detection and amplitude modulation detection in suspected hidden hearing loss

S Vijayasarathy, M Mohan, P Nagalakshmi… - Hearing, Balance and …, 2021 - Taylor & Francis
Objectives The objectives of the study were to investigate speech in noise perception, gap
detection, and amplitude modulation detection in construction workers exposed to …

Repeated moderate sound exposure causes accumulated trauma to cochlear ribbon synapses in mice

Y Luo, T Qu, Q Song, Y Qi, S Yu, S Gong, K Liu, X Jiang - Neuroscience, 2020 - Elsevier
Repeated induction of a temporary threshold shift (TTS) may result in a permanent threshold
shift (PTS) and is thought to be associated with early onset of age-related hearing loss …

Leisure noise exposure and hearing outcomes among Canadians aged 6 to 79 years

K Feder, L Marro, C Portnuff - International Journal of Audiology, 2023 - Taylor & Francis
Objective To examine the association between individual and cumulative leisure noise
exposure in addition to acceptable yearly exposure (AYE) and hearing outcomes among a …

[HTML][HTML] Hidden cochlear impairments

GD Chen - Journal of Otology, 2018 - Elsevier
Pure tone audiometry is a routine clinical examination used to identify hearing loss. A
normal pure tone audiogram is usually taken as evidence of normal hearing. Auditory …

C-Phycocyanin Attenuates Noise-Induced Cochlear Synaptopathy via the Inhibition of Oxidative Stress and Intercellular Adhesion Molecule-1 in the Cochlea

YC Lin, CP Shih, YY Lin, HC Lin, CY Kuo… - International Journal of …, 2024 - mdpi.com
The synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) are the
most vulnerable structures in the noise-exposed cochlea. Cochlear synaptopathy results …

Differences in calcium clearance at inner hair cell active zones may underlie the difference in susceptibility to noise-induced cochlea synaptopathy of C57BL/6J and …

H Liu, H Peng, L Wang, P Xu, Z Wang… - Frontiers in Cell and …, 2021 - frontiersin.org
Noise exposure of a short period at a moderate level can produce permanent cochlear
synaptopathy without seeing lasting changes in audiometric threshold. However, due to the …