Chronic myeloid leukemia (CML) has evolved from an invariably fatal disease to a chronic
disorder that can be treated with targeted drugs and allows survival expectations …

Objective: To explore Fertility and disease outcomes in patients with chronic myeloid
leukemia (CML). Methods: Clinical and fertility outcomes of male (from Jul. 1998 to Feb …

Approximately 10%–12% of patients in chronic-phase chronic myeloid leukemia (CP-CML)
have additional chromosomal aberrations at diagnosis; moreover, CML occurs in up to 10 …

Study design The present study data were obtained when performing the RAND study
(Response and Adherence to Nilotinib in Daily practice), a multicenter observational study …

慢性髓性白血病患者的生育和疾病结局- PMC Back to Top Skip to main content NIH NLM Logo
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Chronic myeloid leukemia is the first example of successful clinical use of tyrosine kinase
inhibitors (TKIs). Blockade of oncogenic BCR-ABL1 tyrosine kinase activity by imatinib …

Preclinical animal studies have demonstrated an association between maternal use of
tyrosine kinase inhibitors and embryofetal toxicity; yet, multiple clinical case series have …

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor
necrosis factor superfamily, triggering apoptosis in malignant cell without affecting healthy …

Pregnancy in chronic myeloid leukaemia (CML) is no longer precluded. Tyrosine kinase
inhibitors (TKI) have resulted in a life expectancy approaching that of non-leukaemic …

The myelodysplastic syndromes (MDS) represent a heterogeneous group of clonal
disorders caused by somatic driver mutations affecting the hematopoietic stem and …