Alternative splicing of mRNA precursors is a nearly ubiquitous and extremely flexible point of
gene control in humans. It provides cells with the opportunity to create protein isoforms of …

The RNA-binding proteins (RBPs) are critical trans factors that associate with specific cis
elements present in mRNAs whose stability and translation are subject to regulation. The …

The regulatory loop between long noncoding RNAs (lncRNAs) and microRNAs has a
dynamic role in transcriptional and translational regulation, and is involved in cancer …

Abstract Argonaute 2 (AGO2), the core component of microRNA (miRNA)-induced silencing
complex, plays a compelling role in tumorigenesis and aggressiveness. However, the …

PARP-1 synthesizes long poly (ADP-ribose) chains (PAR) at DNA damage sites to recruit
DNA repair factors. Among proteins relocated on damaged DNA, the RNA-binding protein …

Although the innate immune response to induce postischemic inflammation is considered as
an essential step in the progression of cerebral ischemia injury, the role of innate immunity …

The cytoplasmic events that control mammalian gene expression, primarily mRNA stability
and translation, potently influence the cellular response to internal and external signals. The …

The control of eukaryotic gene expression occurs at multiple levels, from transcription to
messenger RNA processing, transport, localization, turnover, and translation. RNA-binding …

The p38 mitogen-activated protein kinase (p38MAPK) pathway has been implicated in a
variety of pathological conditions including inflammation and metastasis. Post-transcriptional …

The mammalian RNA-binding protein (RBP) HuR associates with numerous mRNAs
encoding proteins with roles in cell division, cell survival, immune response, and …