Amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis is a fatal CNS neurodegenerative disease. Despite intensive
research, current management of amyotrophic lateral sclerosis remains suboptimal from …
research, current management of amyotrophic lateral sclerosis remains suboptimal from …
TDP-43 proteinopathies: a new wave of neurodegenerative diseases
EMJ De Boer, VK Orie, T Williams, MR Baker… - Journal of Neurology …, 2021 - jnnp.bmj.com
Inclusions of pathogenic deposits containing TAR DNA-binding protein 43 (TDP-43) are
evident in the brain and spinal cord of patients that present across a spectrum of …
evident in the brain and spinal cord of patients that present across a spectrum of …
[PDF][PDF] A proposal for new diagnostic criteria for ALS
1. Background The El Escorial criteria for the diagnosis of Amyotrophic Lateral Sclerosis
(ALS) were initially published in 1994 (Brooks, 1994) and revised in 2000 (Brooks et al …
(ALS) were initially published in 1994 (Brooks, 1994) and revised in 2000 (Brooks et al …
Diagnostic utility of gold coast criteria in amyotrophic lateral sclerosis
A Hannaford, N Pavey, M van den Bos… - Annals of …, 2021 - Wiley Online Library
Objective The diagnosis of amyotrophic lateral sclerosis (ALS) remains problematic, with
current diagnostic criteria (revised El Escorial [rEEC] and Awaji) being complex and prone to …
current diagnostic criteria (revised El Escorial [rEEC] and Awaji) being complex and prone to …
[HTML][HTML] Nontraumatic spinal cord injury: epidemiology, etiology and management
DM Molinares, DR Gater, S Daniel… - Journal of personalized …, 2022 - mdpi.com
The spinal cord is a conduit within the central nervous system (CNS) that provides ongoing
communication between the brain and the rest of the body, conveying complex sensory and …
communication between the brain and the rest of the body, conveying complex sensory and …
[HTML][HTML] The role of sonic hedgehog pathway in the development of the central nervous system and aging-related neurodegenerative diseases
C Yang, Y Qi, Z Sun - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
The Sonic hedgehog (SHH) pathway affects neurogenesis and neural patterning during the
development of the central nervous system. Dysregulation of the SHH pathway in the brain …
development of the central nervous system. Dysregulation of the SHH pathway in the brain …
Advances in molecular pathology, diagnosis, and treatment of amyotrophic lateral sclerosis
H Ilieva, M Vullaganti, J Kwan - bmj, 2023 - bmj.com
Although the past two decades have produced exciting discoveries in the genetics and
pathology of amyotrophic lateral sclerosis (ALS), progress in developing an effective therapy …
pathology of amyotrophic lateral sclerosis (ALS), progress in developing an effective therapy …
Phenotypic categorisation of individual subjects with motor neuron disease based on radiological disease burden patterns: a machine-learning approach
Motor neuron disease is an umbrella term encompassing a multitude of clinically
heterogeneous phenotypes. The early and accurate categorisation of patients is hugely …
heterogeneous phenotypes. The early and accurate categorisation of patients is hugely …
[HTML][HTML] Current state and future directions in the diagnosis of amyotrophic lateral sclerosis
M Vidovic, LH Müschen, S Brakemeier, G Machetanz… - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
loss of upper and lower motor neurons, resulting in progressive weakness of all voluntary …
loss of upper and lower motor neurons, resulting in progressive weakness of all voluntary …
[HTML][HTML] Gold Coast diagnostic criteria increase sensitivity in amyotrophic lateral sclerosis
K Pugdahl, JP Camdessanché, B Cengiz… - Clinical …, 2021 - Elsevier
Objective This study evaluates diagnostic accuracy of the proposed 'Gold Coast'(GC)
diagnostic criteria for amyotrophic lateral sclerosis (ALS). Methods Five European centres …
diagnostic criteria for amyotrophic lateral sclerosis (ALS). Methods Five European centres …