Estrogens, cancer and immunity

I Orzołek, J Sobieraj, J Domagała-Kulawik - Cancers, 2022 - mdpi.com
Simple Summary In this review, we present current knowledge of sex hormones in the
process of development of malignant diseases. The impact of sex hormones on immune …

Role of sex and sex hormones in PD-L1 expression in NSCLC: clinical and therapeutic implications

V Rodriguez-Lara, G Soca-Chafre… - Frontiers in …, 2023 - frontiersin.org
Currently, immunotherapy based on PD-1/PD-L1 pathway blockade has improved survival
of non-small cell lung cancer (NSCLC) patients. However, differential responses have been …

Burden of lung cancer along with attributable risk factors in China from 1990 to 2019, and projections until 2030

Y Fang, Z Li, H Chen, T Zhang, X Yin, J Man… - Journal of Cancer …, 2023 - Springer
Objective This study aimed to identify and project the epidemiological trends and the burden
of lung cancer in China. Methods We extracted incidence, mortality, disability-adjusted life …

Understanding the phytoestrogen genistein actions on breast cancer: Insights on estrogen receptor equivalence, pleiotropic essence and emerging paradigms in …

P Malik, R Singh, M Kumar, A Malik… - Current Topics in …, 2023 - ingentaconnect.com
Prevalent as a major phenolic ingredient of soy and soy products, genistein is recognized as
an eminent phytoestrogen owing to its interacting ability with estrogen receptors (ERs). The …

GPER: An Estrogen Receptor Key in Metastasis and Tumoral Microenvironments

AC Tirado-Garibay, EA Falcón-Ruiz… - International Journal of …, 2023 - mdpi.com
Estrogens and their role in cancer are well-studied, and some cancer types are classified in
terms of their response to them. In recent years, a G protein-coupled estrogen receptor …

[HTML][HTML] Bisphenol A and Di (2-Ethylhexyl) Phthalate promote pulmonary carcinoma in female rats via estrogen receptor beta: In vivo and in silico analysis

M Xiao, Y Zhang, X Zhang, G Zhang, C Jin… - Ecotoxicology and …, 2023 - Elsevier
The prevalence of lung cancer in women currently merits our attentions. However, cigarette
exposure alone does not tell the whole story that lung cancer is more prevalent among non …

[HTML][HTML] Sex disparities in non-small cell lung cancer: mechanistic insights from a cRaf transgenic disease model

S Zhong, J Borlak - EBioMedicine, 2023 - thelancet.com
Background Women are at greater risk of developing non-small cell lung cancer (NSCLC),
yet the underlying causes remain unclear. Methods We performed whole genome scans in …

Immune characteristics analysis and construction of a four-gene prognostic signature for lung adenocarcinoma based on estrogen reactivity

Y Wang, T Yu, J Chen, R Zhao, M Diao, P Mei, S He… - BMC cancer, 2023 - Springer
Lung adenocarcinoma (LUAD) is a common type of malignant tumor with poor prognosis
and high mortality. In our previous studies, we found that estrogen is an important risk factor …

Exogenous Estrogen in the Development of Head and Neck Cancer

C Doll, E Hofmann, R Preissner… - … –Head & Neck …, 2024 - jamanetwork.com
Importance Sex differences in head and neck cancer (HNC) incidence suggest a potential
contribution of sex hormones. Objective To assess the role of exogenous estrogen exposure …

[PDF][PDF] Dual Effect of Immune Cells within Tumour Microenvironment: Pro-and Anti-Tumour Effects and Their Triggers. Cancers 2022, 14, 1681

AC Peña-Romero, E Orenes-Piñero - 2022 - mdpi.com
Our body is constantly exposed to pathogens or external threats, but with the immune
response that our body can develop, we can fight off and defeat possible attacks or …