Gene expression data are exponentially accumulating; thus, the functional annotation of
such sequence data from metadata is urgently required. However, life scientists have …

Isocitrate dehydrogenases (IDHs) are enzymes that catalyze the oxidative decarboxylation
of isocitrate, producing α-ketoglutarate (αKG) and CO2. The discovery of IDH1 and IDH2 …

Hypoxia is a common feature in solid tumors and is associated with cancer progression. The
main regulators of the hypoxic response are hypoxia-inducible transcription factors (HIFs) …

Skeletal muscles are composed of heterogeneous collections of fibers with different
metabolic profiles. With varied neuronal innervation and fiber-type compositions, each …

Breast cancer is the 2nd leading cause of cancer-related death among women. Increased
risk of breast cancer has been associated with high dietary cholesterol intake. However, the …

Abstract" Oncometabolite" 2-hydroxyglutarate (2-HG) is an aberrant metabolite found in
tumor cells, exerting a pivotal influence on tumor progression. Recent studies have unveiled …

Covering: 1993 to 2016 The exploitation of small molecules from natural sources, such as
microbial metabolites, has contributed to the discovery of not only new drugs but also new …

The precise molecular mechanism of hepatocellular carcinoma (HCC) remains ambiguous.
Isocitrate dehydrogenase 3A (IDH3A) is known as a subunit of the IDH3 heterotetramer. To …

Mitochondria-related metabolic reprogramming plays a major role in the occurrence,
development, drug resistance, and recurrence of acute myeloid leukemia (AML). However …

Aims In tumor cells, shikonin treatment has been reported to inhibit glycolysis by
suppressing the activity of pyruvate kinase M2 (PKM2) and to induce apoptosis by …