Objective: To observe the restraining effect of IL-38 on inflammatory response in collagen-
induced arthritis rats (CIA), and to explore the regulatory mechanism of SIRT1/HIF-1α …

Lymphocyte antigen 6 complex, locus E (LY6E) has been implicated in the malignant
progression of various types of cancers; however, the underlying mechanism remains …

Hypoxia-inducible factor-1α (HIF-1α) is a major transcriptional factor, which plays an
important role in cellular reprogramming processes under hypoxic conditions, which …

The characteristic feature of a cancer microenvironment is the presence of a highly elevated
concentration of L-lactate in the tumor niche. The lactate-rich environment is also maintained …

Eukaryotic NAD-dependent isocitrate dehydrogenases (NAD-IDHs) are mitochondria-
localized enzymes which catalyze the oxidative decarboxylation of isocitrate to α …

The search for mitochondria-targeted drugs has dramatically risen over the last decade.
Mitochondria are essential organelles serving not only as a powerhouse of the cell but also …

Cardiac‐cerebral thrombosis and malignant tumor endanger the safety of human life
seriously. Traditional chemotherapy drugs have side effects which restrict their applications …

Long non-coding RNAs (lncRNAs) are a novel class of non-coding RNA (ncRNA), that have
been studied extensively in the field of tumor research in recent years. In the case of tumor …

Human NAD-dependent isocitrate dehydrogenase existing as the α2βγ heterotetramer,
catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the Krebs cycle, and is …

Hypoxic and stroma-rich microenvironments, characteristic features of pancreatic cancers,
are strongly associated with a poor prognosis. However, whether and how hypoxia …