Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity

R Lang, AL Gundlach, FE Holmes, SA Hobson… - Pharmacological …, 2015 - ASPET
Galanin was first identified 30 years ago as a" classic neuropeptide," with actions primarily
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …

Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour

EG Mills, C Izzi-Engbeaya, A Abbara… - Nature Reviews …, 2021 - nature.com
The bioactive peptides galanin, spexin and kisspeptin have a common ancestral origin and
their pathophysiological roles are increasingly the subject of investigation. Evidence …

Neurobiology of addiction: An integrative review

A Goodman - Biochemical pharmacology, 2008 - Elsevier
Evidence that psychoactive substance use disorders, bulimia nervosa, pathological
gambling, and sexual addiction share an underlying biopsychological process is …

Role of neuropeptides in appetite regulation and obesity–a review

S Arora - Neuropeptides, 2006 - Elsevier
Obesity represents the most prevalent nutritional problem worldwide which in the long run
predisposes to development of diabetes mellitus, hypertension, endometrial carcinoma …

Maternal high-fat diet and fetal programming: increased proliferation of hypothalamic peptide-producing neurons that increase risk for overeating and obesity

GQ Chang, V Gaysinskaya, O Karatayev… - Journal of …, 2008 - Soc Neuroscience
Recent studies in adult and weanling rats show that dietary fat, in close association with
circulating lipids, can stimulate expression of hypothalamic peptides involved in controlling …

Hypothalamic serotonin in control of eating behavior, meal size, and body weight

SF Leibowitz, JT Alexander - Biological psychiatry, 1998 - Elsevier
Serotonin (5-HT) has been implicated in the control of eating behavior and body weight.
Stimulants of this monoamine reduce food intake and weight gain and increase energy …

The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease

R Lang, AL Gundlach, B Kofler - Pharmacology & therapeutics, 2007 - Elsevier
The galanin peptide family consists of the “parental” galanin, galanin-message-associated
peptide (GMAP) which derives from the same peptide precursor gene product as galanin …

Cancer anorexia-cachexia syndrome: are neuropeptides the key?

A Inui - Cancer research, 1999 - AACR
Progressive wasting is common in many types of cancer and is one of the most important
factors leading to early death in cancer patients. Weight loss is a potent stimulus to food …

Perinatal elevation of hypothalamic insulin, acquired malformation of hypothalamic galaninergic neurons, and syndrome x-like alterations in adulthood of neonatally …

A Plagemann, T Harder, A Rake, M Voits, H Fink… - Brain research, 1999 - Elsevier
Overnutrition during critical developmental periods is suggested to be a risk factor for obesity
and associated metabolic disorders in later life. Underlying mechanisms are unknown …

Hypothalamic control of energy balance: different peptides, different functions

SF Leibowitz, KE Wortley - Peptides, 2004 - Elsevier
Energy balance is maintained via a homeostatic system involving both the brain and the
periphery. A key component of this system is the hypothalamus. Over the past two decades …