Macrophages are important immune cells in innate immunity, and have remarkable
heterogeneity and polarization. Under pathological conditions, in addition to the resident …

Macrophages are crucial cells in the human body's innate immunity and are engaged in a
variety of non-inflammatory reactions. Macrophages can develop into two kinds when …

Objective In rheumatoid arthritis (RA), elevated serum interleukin‐34 (IL‐34) levels are
linked with increased disease severity. IL‐34 binds to 2 receptors, macrophage colony …

Macrophages can be polarized into two subsets: a proinflammatory (M1) or an anti-
inflammatory (M2) phenotype. In this study, we show that an increased M1-to-M2 ratio …

Introduction Scurfy mice have a complete deficiency of functional regulatory T cells (Treg)
due to a frameshift mutation in the Foxp3 gene. The impaired immune homeostasis results in …

Rheumatoid arthritis (RA) is a chronic autoimmune disease with a multifaceted etiology,
which primarily affects and results in the deterioration of the synovium of patients. While the …

Myeloid cell mediated mechanisms regulate synovial joint inflammation. IL-34, a
macrophage (Mø) growth and differentiation molecule, is markedly expressed in neutrophil …

Liver disease is a global health problem and is a primary cause of mortality and morbidity
worldwide. Specifically, it accounts for approximately two million deaths per year worldwide …

巨噬细胞作为重要的免疫细胞, 参与维持肝内微环境稳态的关键过程. 近年研究发现不同肝脏
疾病均可诱发巨噬细胞极化(MPP), 形成功能互为拮抗的M1 和M2 表型, 前者可促进清除病原体 …

Background Autoimmune hepatitis (AIH) is a chronic immune-mediated inflammatory liver
disease. At present, it is largely unknown how the innate immune cells influence AIH …