Macrophage polarization and its role in liver disease
C Wang, C Ma, L Gong, Y Guo, K Fu, Y Zhang… - Frontiers in …, 2021 - frontiersin.org
Macrophages are important immune cells in innate immunity, and have remarkable
heterogeneity and polarization. Under pathological conditions, in addition to the resident …
heterogeneity and polarization. Under pathological conditions, in addition to the resident …
Macrophage polarization: an important role in inflammatory diseases
M Luo, F Zhao, H Cheng, M Su, Y Wang - Frontiers in Immunology, 2024 - frontiersin.org
Macrophages are crucial cells in the human body's innate immunity and are engaged in a
variety of non-inflammatory reactions. Macrophages can develop into two kinds when …
variety of non-inflammatory reactions. Macrophages can develop into two kinds when …
Interleukin‐34 Reprograms Glycolytic and Osteoclastic Rheumatoid Arthritis Macrophages via Syndecan 1 and Macrophage Colony‐Stimulating Factor Receptor
K Van Raemdonck, S Umar… - Arthritis & …, 2021 - Wiley Online Library
Objective In rheumatoid arthritis (RA), elevated serum interleukin‐34 (IL‐34) levels are
linked with increased disease severity. IL‐34 binds to 2 receptors, macrophage colony …
linked with increased disease severity. IL‐34 binds to 2 receptors, macrophage colony …
[HTML][HTML] IL-34 Downregulation‒Associated M1/M2 Macrophage Imbalance Is Related to Inflammaging in Sun-Exposed Human Skin
S Horiba, R Kami, T Tsutsui, J Hosoi - JID Innovations, 2022 - Elsevier
Macrophages can be polarized into two subsets: a proinflammatory (M1) or an anti-
inflammatory (M2) phenotype. In this study, we show that an increased M1-to-M2 ratio …
inflammatory (M2) phenotype. In this study, we show that an increased M1-to-M2 ratio …
Regulatory T-cell deficiency leads to features of autoimmune liver disease overlap syndrome in scurfy mice
K Yilmaz, S Haeberle, YO Kim, MJ Fritzler… - Frontiers in …, 2023 - frontiersin.org
Introduction Scurfy mice have a complete deficiency of functional regulatory T cells (Treg)
due to a frameshift mutation in the Foxp3 gene. The impaired immune homeostasis results in …
due to a frameshift mutation in the Foxp3 gene. The impaired immune homeostasis results in …
Interleukin-34-regulated T-cell responses in rheumatoid arthritis
HE Park, H Oh, JH Baek - Frontiers in Medicine, 2022 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic autoimmune disease with a multifaceted etiology,
which primarily affects and results in the deterioration of the synovium of patients. While the …
which primarily affects and results in the deterioration of the synovium of patients. While the …
[HTML][HTML] IL-34 and protein-tyrosine phosphatase receptor type-zeta-dependent mechanisms limit arthritis in mice
HM González-Sánchez, JH Baek… - Laboratory …, 2022 - Elsevier
Myeloid cell mediated mechanisms regulate synovial joint inflammation. IL-34, a
macrophage (Mø) growth and differentiation molecule, is markedly expressed in neutrophil …
macrophage (Mø) growth and differentiation molecule, is markedly expressed in neutrophil …
Recent insights of the role and signalling pathways of interleukin-34 in liver diseases
F Al-Shaebi, L Wenzhang, K Hezam… - International …, 2020 - Elsevier
Liver disease is a global health problem and is a primary cause of mortality and morbidity
worldwide. Specifically, it accounts for approximately two million deaths per year worldwide …
worldwide. Specifically, it accounts for approximately two million deaths per year worldwide …
巨噬细胞极化在非肿瘤性肝脏疾病中的作用机制及其靶向治疗.
陈玮钰, 覃小宾, 乐滢玉, 王涵… - Journal of Clinical …, 2022 - search.ebscohost.com
巨噬细胞作为重要的免疫细胞, 参与维持肝内微环境稳态的关键过程. 近年研究发现不同肝脏
疾病均可诱发巨噬细胞极化(MPP), 形成功能互为拮抗的M1 和M2 表型, 前者可促进清除病原体 …
疾病均可诱发巨噬细胞极化(MPP), 形成功能互为拮抗的M1 和M2 表型, 前者可促进清除病原体 …
The imbalance of liver resident macrophages polarization promotes chronic autoimmune hepatitis development in mice
G Chi, J Pei, X Li - PeerJ, 2023 - peerj.com
Background Autoimmune hepatitis (AIH) is a chronic immune-mediated inflammatory liver
disease. At present, it is largely unknown how the innate immune cells influence AIH …
disease. At present, it is largely unknown how the innate immune cells influence AIH …