Cancer is still one of the major causes of death worldwide. Even if its comprehension is
improving continuously, the complexity and heterogeneity of this group of diseases …

Optimal control theory is branch of mathematics that aims to optimize a solution to a
dynamical system. While the concept of using optimal control theory to improve treatment …

In the absence of curative therapies, treatment of metastatic castrate-resistant prostate
cancer (mCRPC) using currently available drugs can be improved by integrating …

Recent clinical trials have shown that adaptive drug therapies can be more efficient than a
standard cancer treatment based on a continuous use of maximum tolerated doses (MTD) …

Cancer is an uncontrollable growth of abnormal cells in any tissue of the body. Many
researchers have focused on machine learning and artificial intelligence (AI) based on …

Prostate cancer can be lethal in advanced stages, for which chemotherapy may become the
only viable therapeutic option. While there is no clear clinical management strategy fitting all …

The long-term efficacy of targeted therapeutics for cancer treatment can be significantly
limited by the type of therapy and development of drug resistance, inter alia. Experimental …

In this context, we introduce a multi-objective optimization problem (MOOP) to
simultaneously minimize the objectives of cancerous cells density as well as the approved …

On drug resistance and metronomic chemotherapy: A mathematical modeling and optimal
control approach AIMS share this content in Facebook share this content in Twitter share …

Despite being one of the first countries to implement mass drug administration (MDA) for
elimination of lymphatic filariasis (LF) in 2001 after a pilot study in 2000, the Philippines is …