Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity

R Lang, AL Gundlach, FE Holmes, SA Hobson… - Pharmacological …, 2015 - ASPET
Galanin was first identified 30 years ago as a" classic neuropeptide," with actions primarily
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …

The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease

R Lang, AL Gundlach, B Kofler - Pharmacology & therapeutics, 2007 - Elsevier
The galanin peptide family consists of the “parental” galanin, galanin-message-associated
peptide (GMAP) which derives from the same peptide precursor gene product as galanin …

Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat

MS Irwig, GS Fraley, JT Smith, BV Acohido… - …, 2005 - karger.com
The KiSS-1 gene codes for a family of neuropeptides called kisspeptins which bind to the G-
protein-coupled receptor GPR54. To assess the possible effects of kisspeptins on …

Rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion, and has variable effects on sex behavior in the adult male rat

MA Johnson, K Tsutsui, GS Fraley - Hormones and behavior, 2007 - Elsevier
A recently described avian neuropeptide, gonadotropin inhibitory hormone (GnIH), has been
shown to have seasonal regulatory effects on the hypothalamic–pituitary–gonadotropin axis …

Hypothalamic neuropeptides and the regulation of appetite

JA Parker, SR Bloom - Neuropharmacology, 2012 - Elsevier
Neuropeptides released by hypothalamic neurons play a major role in the regulation of
feeding, acting both within the hypothalamus, and at other appetite regulating centres …

Hypothalamic control of energy balance: different peptides, different functions

SF Leibowitz, KE Wortley - Peptides, 2004 - Elsevier
Energy balance is maintained via a homeostatic system involving both the brain and the
periphery. A key component of this system is the hypothalamus. Over the past two decades …

Galanin-like peptide (GALP) is a hypothalamic regulator of energy homeostasis and reproduction

C Lawrence, GS Fraley - Frontiers in neuroendocrinology, 2011 - Elsevier
Galanin-like peptide (GALP) was discovered in 1999 in the porcine hypothalamus and was
found to be a 60 amino acid neuropeptide. GALP shares sequence homology to galanin (1 …

Effects of galanin-like peptide (GALP) on locomotion, reproduction, and body weight in female and male mice

AS Kauffman, J Buenzle, GS Fraley, EF Rissman - Hormones and behavior, 2005 - Elsevier
Galanin-like peptide (GALP) has been implicated in the neuroendocrine regulation of both
feeding and reproduction. In male rodents and primates, intracerebroventricular (icv) …

Alarin stimulates food intake in male rats and LH secretion in castrated male rats

N Van Der Kolk, FN Madison, M Mohr, N Eberhard… - Neuropeptides, 2010 - Elsevier
Alarin is a newly identified member of the galanin family of neuropeptides that includes
galanin-like peptide (GALP) and galanin. Alarin was discovered as an alternate transcript of …

Galanin-like peptide as a link in the integration of metabolism and reproduction

ML Gottsch, DK Clifton, RA Steiner - Trends in Endocrinology & Metabolism, 2004 - cell.com
The arcuate nucleus is a hypothalamic center that couples energetics and reproduction.
Peptide-releasing neurons in the arcuate nucleus receive and process humoral signals from …