Voltage-gated Ca2+ channels (VGCCs) are voltage sensors that convert membrane
depolarizations into Ca2+ signals. In the chromaffin cells of the adrenal medulla, the Ca2+ …

The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor (GPCR) that is
expressed in several brain nuclei playing a crucial role in the regulation of energy balance …

Histamine, a neurotransmitter/neuromodulator implicated in the control of arousal state,
exerts a potent phase‐shifting effect on the circadian clock in the rodent suprachiasmatic …

Whole-genome sequencing was performed on 3 bipolar I disorder (BPI) cases from a
multiplex pedigree of European ancestry with 7 BPI cases. Within CACNA1D, a gene …

Ca2+-dependent inactivation (CDI) is a negative feedback regulation of voltage-gated Cav1
and Cav2 channels that is mediated by the Ca2+ sensing protein, calmodulin (CaM) …

The L-type calcium channel blocker nimodipine improves clinical outcome produced by
delayed cortical ischemia or vasospasm associated with subarachnoid hemorrhage. While …

Further understanding of how prefrontal cortex (PFC) circuit change during postnatal
development is of great interest due to its role in working memory and decision-making, two …

Objective An increase of neuronal Cav1. 3 L‐type calcium channels (LTCC s) has been
observed in various animal models of epilepsy. However, LTCC inhibitors failed in clinical …

Voltage-gated L-type calcium channels (LTCCs) are expressed in adrenal chromaffin cells.
Besides shaping the action potential (AP), LTCCs are involved in the excitation-secretion …

Background While recent genome-wide association studies have identified several new
bipolar disorder (BD) risk variants, structural imaging studies have reported enlarged …