[HTML][HTML] Membrane-type matrix metalloproteinases: Their functions and regulations
Y Itoh - Matrix Biology, 2015 - Elsevier
Membrane-type matrix metalloproteinases (MT-MMPs) form a subgroup of the matrix
metalloproteinase (MMP) family, and there are 6 MT-MMPs in humans. MT-MMPs are further …
metalloproteinase (MMP) family, and there are 6 MT-MMPs in humans. MT-MMPs are further …
Human matrix metalloproteinases: an ubiquitarian class of enzymes involved in several pathological processes
D Sbardella, GF Fasciglione, M Gioia, C Ciaccio… - Molecular aspects of …, 2012 - Elsevier
Human matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of
endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site …
endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site …
[HTML][HTML] Membrane-type matrix metalloproteases as diverse effectors of cancer progression
SP Turunen, O Tatti-Bugaeva, K Lehti - Biochimica et Biophysica Acta (BBA …, 2017 - Elsevier
Membrane-type matrix metalloproteases (MT-MMP) are pivotal regulators of cell invasion,
growth and survival. Tethered to the cell membranes by a transmembrane domain or GPI …
growth and survival. Tethered to the cell membranes by a transmembrane domain or GPI …
[HTML][HTML] Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-α convertase activity but does not activate pro-MMP2
WR English, XS Puente, JMP Freije… - Journal of Biological …, 2000 - ASBMB
Membrane type 4 matrix metalloproteinase (MT4-MMP) shows the least sequence homology
to the other MT-MMPs, suggesting a distinct function for this protein. We have isolated a …
to the other MT-MMPs, suggesting a distinct function for this protein. We have isolated a …
[HTML][HTML] Claudin promotes activation of pro-matrix metalloproteinase-2 mediated by membrane-type matrix metalloproteinases
H Miyamori, T Takino, Y Kobayashi, H Tokai… - Journal of Biological …, 2001 - ASBMB
Genes associated with regulation of membrane-type matrix metalloproteinase-1 (MT1-MMP)-
mediated pro-MMP-2 processing were screened in 293T cells by a newly developed …
mediated pro-MMP-2 processing were screened in 293T cells by a newly developed …
Coordinate action of membranetype matrix metalloproteinase1 (MT1MMP) and MMP2 enhances pericellular proteolysis and invasion
H Sato, T Takino - Cancer science, 2010 - Wiley Online Library
Membranetype matrix metalloproteinase1 (MT1MMP) mediates cleavage of not only
MMP2/gelatinase A for activation, but also a variety of substrates including type I collagen …
MMP2/gelatinase A for activation, but also a variety of substrates including type I collagen …
MMPs and TIMPs—an historical perspective
JF Woessner - Molecular biotechnology, 2002 - Springer
There are currently 25 known vertebrate matrix metalloproteinases (MMPs) and 4 tissue
inhibitors of metalloproteinases (TIMPs). This article reviews these proteases from an …
inhibitors of metalloproteinases (TIMPs). This article reviews these proteases from an …
MT4-(MMP17) and MT6-MMP (MMP25), A unique set of membrane-anchored matrix metalloproteinases: properties and expression in cancer
A Sohail, Q Sun, H Zhao, MM Bernardo, JA Cho… - Cancer and Metastasis …, 2008 - Springer
The process of cancer progression involves the action of multiple proteolytic systems,
among which the family of matrix metalloproteinases (MMPs) play a pivotal role. The MMPs …
among which the family of matrix metalloproteinases (MMPs) play a pivotal role. The MMPs …
[HTML][HTML] Catalytic activities of membrane-type 6 matrix metalloproteinase (MMP25)
WR English, G Velasco, JO Stracke, V Knäuper… - FEBS letters, 2001 - Elsevier
This study describes the biochemical characterisation of the catalytic domain of membrane-
type 6 matrix metalloproteinase (MT6-MMP, MMP25, leukolysin). Its activity towards …
type 6 matrix metalloproteinase (MT6-MMP, MMP25, leukolysin). Its activity towards …
New strategies for the next generation of matrixmetalloproteinase inhibitors: selectively targeting membraneanchored MMPs with therapeutic antibodies
L Devy, DT Dransfield - Biochemistry research international, 2011 - Wiley Online Library
MMP intervention strategies have met with limited clinical success due to severe toxicities. In
particular, treatment with broadspectrum MMPinhibitors (MMPIs) caused musculoskeletal …
particular, treatment with broadspectrum MMPinhibitors (MMPIs) caused musculoskeletal …