Proteasome-independent K63 polyubiquitination selectively regulates ATP levels and proteasome activity during fear memory formation in the female amygdala

K Farrell, M Musaus, A Auerbach, S Navabpour… - Molecular …, 2023 - nature.com
Females are more likely than males to develop post-traumatic stress disorder (PTSD).
However, the neurobiological mechanisms responsible for these sex differences remain …

[HTML][HTML] Sex-differences in proteasome-dependent K48-polyubiquitin signaling in the amygdala are developmentally regulated in rats

K Farrell, A Auerbach, C Liu, K Martin, M Pareno… - Biology of sex …, 2023 - Springer
Background Sex differences have been observed in several brain regions for the molecular
mechanisms involved in baseline (resting) and memory-related processes. The ubiquitin …

The Ubiquitin Tale: Current Strategies and Future Challenges

A Upadhyay, V Joshi - ACS Pharmacology & Translational …, 2024 - ACS Publications
Ubiquitin (Ub) is often considered a structurally conserved protein. Ubiquitination plays a
prominent role in the regulation of physiological pathways. Since the first mention of Ub in …

[HTML][HTML] Bioinformatics analysis of diagnostic biomarkers for Alzheimer's disease in peripheral blood based on sex differences and support vector machine algorithm

W Ji, K An, C Wang, S Wang - Hereditas, 2022 - Springer
Abstract Background The prevalence of Alzheimer's disease (AD) varies based on gender.
Due to the lack of early stage biomarkers, most of them are diagnosed at the terminal stage …

The epigenetic role of proteasome subunit RPT6 during memory formation in female rats

K Farrell, A Auerbach, M Musaus… - Learning & …, 2022 - learnmem.cshlp.org
Reports of sex differences in the neurobiology of memory formation are becoming more
prevalent. Despite this, much remains unknown about the role of sex in this process. We …

[HTML][HTML] Paternal preconceptional diet enriched with n-3 polyunsaturated fatty acids affects offspring brain function in mice

M Li, Q Shi, X Jiang, X Liu, W Han, X Fan, P Li… - Frontiers in …, 2022 - frontiersin.org
Recent studies demonstrate that paternal nutrition prior to conception may determine
offspring development and health through epigenetic modification. This study aims to …

Endocrine disruptor-induced epimutagenesis in vitro: Insight into molecular mechanisms

JD Lehle, YH Lin, A Gomez, L Chavez, JR McCarrey - bioRxiv, 2024 - biorxiv.org
Endocrine disrupting chemicals (EDCs) such as bisphenol S (BPS) are xenobiotic
compounds that can disrupt endocrine signaling following exposure due to steric similarities …

Estradiol regulates local synthesis of synaptic proteome via sex-specific mechanisms.

P Raval, H Rae, RRR Duarte, IA Watson, K Sellers… - bioRxiv, 2023 - biorxiv.org
Estrogens, specifically 17β-estradiol (estradiol), can modulate synaptic function by
regulating the expression and localisation of synaptic proteins. However, the mechanisms …

Investigation of the Role of the G-Protein-Coupled Estrogen Receptor in Memory Consolidation in Gonadectomized Male Mice

GDB Machado - 2023 - search.proquest.com
Estrogens are cholesterol-derived hormones that play crucial physiological and pathological
roles in both sexes and across the lifespan. Many research groups have replicated the …

[PDF][PDF] Estradiol regulates local synthesis of synaptic proteome via sex-specific mechanisms.

P Srivastava - storage.prod.researchhub.com
Abstract Estrogens, specifically 17³-estradiol (estradiol), can modulate synaptic function by
regulating the expression and localisation of synaptic proteins. However, the mechanisms …