Among human leukocyte antigen (HLA)-associated disorders, celiac disease has an
immunopathogenesis that is particularly well understood. The condition is characterized by …

The intestinal mucosal barrier, also referred to as intestinal barrier, is widely recognized as a
critical player in gut homeostasis maintenance as it ensures the complex crosstalk between …

Development of the human intestine is not well understood. Here, we link single-cell RNA
sequencing and spatial transcriptomics to characterize intestinal morphogenesis through …

The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6)
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …

Barrier epithelia depend upon resident stem cells for homeostasis, defense, and repair.
Epithelial stem cells of small and large intestines (ISCs) respond to their local …

Cancer cells are regulated by oncogenic mutations and microenvironmental signals, yet
these processes are often studied separately. To functionally map how cell-intrinsic and cell …

Intestinal epithelial cells derive from stem cells at the crypt base and travel along the crypt-
villus axis to die at the villus tip. The two dominant villus epithelial cell types, absorptive …

Stem cells play central roles in tissue development, homeostasis, and regeneration.
Decades of scientific research have uncovered processes of stem cell decline in tissue and …

Tissue engineering is an advanced and potential biomedical approach to treat patients
suffering from lost or failed an organ or tissue to repair and regenerate damaged tissues that …

Intestinal organoids are fundamental in vitro tools that have enabled new research
opportunities in intestinal stem cell research. Organoids can also be transplanted in vivo …