[HTML][HTML] Targeting integrin pathways: mechanisms and advances in therapy
X Pang, X He, Z Qiu, H Zhang, R Xie, Z Liu… - … and Targeted Therapy, 2023 - nature.com
Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …
Friend or foe? The elusive role of hepatic stellate cells in liver cancer
B Cogliati, CN Yashaswini, S Wang, D Sia… - Nature Reviews …, 2023 - nature.com
Liver fibrosis is a substantial risk factor for the development and progression of liver cancer,
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …
[HTML][HTML] Integrins in cancer: Emerging mechanisms and therapeutic opportunities
F Liu, Q Wu, Z Dong, K Liu - Pharmacology & therapeutics, 2023 - Elsevier
Integrins are vital surface adhesion receptors that mediate interactions between the
extracellular matrix (ECM) and cells and are essential for cell migration and the …
extracellular matrix (ECM) and cells and are essential for cell migration and the …
[HTML][HTML] The molecular mechanisms of liver fibrosis and its potential therapy in application
D Zhang, Y Zhang, B Sun - International Journal of Molecular Sciences, 2022 - mdpi.com
Liver fibrosis results from repeated and persistent liver damage. It can start with hepatocyte
injury and advance to inflammation, which recruits and activates additional liver immune …
injury and advance to inflammation, which recruits and activates additional liver immune …
A novel “inside‐out” intraocular nanomedicine delivery mode for nanomaterials' biological effect enhanced choroidal neovascularization occlusion and …
Y Jin, Y Guo, J Yang, X Chu, X Huang… - Advanced …, 2023 - Wiley Online Library
Photodynamic therapy (PDT) is commonly used in choroidal neovascularization (CNV)
treatment due to the superior light transmittance of the eye. However, PDT often leads to …
treatment due to the superior light transmittance of the eye. However, PDT often leads to …
[HTML][HTML] Targeting integrins for cancer therapy-disappointments and opportunities
C Bergonzini, K Kroese, AJM Zweemer… - Frontiers in Cell and …, 2022 - frontiersin.org
Integrins mediate adhesive interactions between cells and their environment, including
neighboring cells and extracellular matrix (ECM). These heterodimeric transmembrane …
neighboring cells and extracellular matrix (ECM). These heterodimeric transmembrane …
[HTML][HTML] Anti-inflammatory therapeutic mechanisms of natural products: insight from rosemary diterpenes, carnosic acid and carnosol
S Habtemariam - Biomedicines, 2023 - mdpi.com
Carnosic acid (CA) and carnosol (CAR) are two major diterpenes of the rosemary plant
(Rosmarinus officinalis). They possess a phenolic structural moiety and are endowed with …
(Rosmarinus officinalis). They possess a phenolic structural moiety and are endowed with …
[HTML][HTML] Recent advance of liposome nanoparticles for nucleic acid therapy
Y Gao, X Liu, N Chen, X Yang, F Tang - Pharmaceutics, 2023 - mdpi.com
Gene therapy, as an emerging therapeutic approach, has shown remarkable advantages in
the treatment of some major diseases. With the deepening of genomics research, people …
the treatment of some major diseases. With the deepening of genomics research, people …
Biological and therapeutic implications of the tumor microenvironment in pituitary adenomas
Pituitary adenomas (PAs) are neoplasms derived from the endocrine cells of the anterior
pituitary gland. Most frequently, they are benign tumors, but may sometimes display an …
pituitary gland. Most frequently, they are benign tumors, but may sometimes display an …
[HTML][HTML] Integrin signaling in cancer: bidirectional mechanisms and therapeutic opportunities
S Li, C Sampson, C Liu, H Piao, HX Liu - Cell Communication and …, 2023 - Springer
Integrins are transmembrane receptors that possess distinct ligand-binding specificities in
the extracellular domain and signaling properties in the cytoplasmic domain. While most …
the extracellular domain and signaling properties in the cytoplasmic domain. While most …