[HTML][HTML] Targeting integrin pathways: mechanisms and advances in therapy

X Pang, X He, Z Qiu, H Zhang, R Xie, Z Liu… - … and Targeted Therapy, 2023 - nature.com
Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Friend or foe? The elusive role of hepatic stellate cells in liver cancer

B Cogliati, CN Yashaswini, S Wang, D Sia… - Nature Reviews …, 2023 - nature.com
Liver fibrosis is a substantial risk factor for the development and progression of liver cancer,
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …

[HTML][HTML] Integrins in cancer: Emerging mechanisms and therapeutic opportunities

F Liu, Q Wu, Z Dong, K Liu - Pharmacology & therapeutics, 2023 - Elsevier
Integrins are vital surface adhesion receptors that mediate interactions between the
extracellular matrix (ECM) and cells and are essential for cell migration and the …

[HTML][HTML] The molecular mechanisms of liver fibrosis and its potential therapy in application

D Zhang, Y Zhang, B Sun - International Journal of Molecular Sciences, 2022 - mdpi.com
Liver fibrosis results from repeated and persistent liver damage. It can start with hepatocyte
injury and advance to inflammation, which recruits and activates additional liver immune …

A novel “inside‐out” intraocular nanomedicine delivery mode for nanomaterials' biological effect enhanced choroidal neovascularization occlusion and …

Y Jin, Y Guo, J Yang, X Chu, X Huang… - Advanced …, 2023 - Wiley Online Library
Photodynamic therapy (PDT) is commonly used in choroidal neovascularization (CNV)
treatment due to the superior light transmittance of the eye. However, PDT often leads to …

[HTML][HTML] Targeting integrins for cancer therapy-disappointments and opportunities

C Bergonzini, K Kroese, AJM Zweemer… - Frontiers in Cell and …, 2022 - frontiersin.org
Integrins mediate adhesive interactions between cells and their environment, including
neighboring cells and extracellular matrix (ECM). These heterodimeric transmembrane …

[HTML][HTML] Anti-inflammatory therapeutic mechanisms of natural products: insight from rosemary diterpenes, carnosic acid and carnosol

S Habtemariam - Biomedicines, 2023 - mdpi.com
Carnosic acid (CA) and carnosol (CAR) are two major diterpenes of the rosemary plant
(Rosmarinus officinalis). They possess a phenolic structural moiety and are endowed with …

[HTML][HTML] Recent advance of liposome nanoparticles for nucleic acid therapy

Y Gao, X Liu, N Chen, X Yang, F Tang - Pharmaceutics, 2023 - mdpi.com
Gene therapy, as an emerging therapeutic approach, has shown remarkable advantages in
the treatment of some major diseases. With the deepening of genomics research, people …

Biological and therapeutic implications of the tumor microenvironment in pituitary adenomas

MD Ilie, A Vasiljevic, P Bertolino, G Raverot - Endocrine reviews, 2023 - academic.oup.com
Pituitary adenomas (PAs) are neoplasms derived from the endocrine cells of the anterior
pituitary gland. Most frequently, they are benign tumors, but may sometimes display an …

[HTML][HTML] Integrin signaling in cancer: bidirectional mechanisms and therapeutic opportunities

S Li, C Sampson, C Liu, H Piao, HX Liu - Cell Communication and …, 2023 - Springer
Integrins are transmembrane receptors that possess distinct ligand-binding specificities in
the extracellular domain and signaling properties in the cytoplasmic domain. While most …