The purpose of this study was to determine the toxicological and pharmacokinetic properties
of sucralose-6-acetate, a structural analog of the artificial sweetener sucralose. Sucralose-6 …

Metabolic reprogramming is an important hallmark of malignant tumors. Serine is a non-
essential amino acid involved in cell proliferation. Serine metabolism, especially the de novo …

Multitargeted agents provide tumor selectivity with reduced drug resistance and dose-
limiting toxicities. We previously described the multitargeted 6-substituted pyrrolo [3, 2-d] …

We previously discovered first-in-class multitargeted 5-substituted pyrrolo [3, 2-d] pyrimidine
antifolates that inhibit serine hydroxymethyltransferase 2 (SHMT2), resulting in potent in vitro …

Purpose: To explore the effects of miR-383-5p and serine hydroxymethyltransferase 2
(SHMT2) on the proliferation and migration of lung adenocarcinoma cells. Methods: SHMT2 …

Background In recent years, the role of altered cellular metabolism in tumor progression has
attracted widespread attention. Related metabolic enzymes have also been considered as …

Background: Ubiquitin fold modifier 1 (UFM1) overexpression is associated with cancer cell
proliferation, migration and invasion. However, the roles and pathways of UFM1 in oral …

Purpose Metabolic reprogramming is currently considered a hallmark of tumor and immune
development. It is obviously of interest to identify metabolic enzymes that are associated with …

Background Gastric cancer (GC) is one of the most common malignant tumours in the
digestive system. Serine hydroxymethyltransferase 2 (SHMT2) is one of the key enzymes …