Cation-chloride cotransporters in neuronal development, plasticity and disease
Electrical activity in neurons requires a seamless functional coupling between
plasmalemmal ion channels and ion transporters. Although ion channels have been studied …
plasmalemmal ion channels and ion transporters. Although ion channels have been studied …
GABAergic interneurons shape the functional maturation of the cortex
C Le Magueresse, H Monyer - Neuron, 2013 - cell.com
From early embryonic development to adulthood, GABA release participates in the
construction of the mammalian cerebral cortex. The maturation of GABAergic …
construction of the mammalian cerebral cortex. The maturation of GABAergic …
[HTML][HTML] The glutamate–glutamine (GABA) cycle: importance of late postnatal development and potential reciprocal interactions between biosynthesis and degradation
L Hertz - Frontiers in endocrinology, 2013 - frontiersin.org
The gold standard for studies of glutamate–glutamine (GABA) cycling and its connections to
brain biosynthesis from glucose of glutamate and GABA and their subsequent metabolism …
brain biosynthesis from glucose of glutamate and GABA and their subsequent metabolism …
Neuronal K+-Cl- cotransporter KCC2 as a promising drug target for epilepsy treatment
E McMoneagle, J Zhou, S Zhang, W Huang… - Acta Pharmacologica …, 2024 - nature.com
Epilepsy is a prevalent neurological disorder characterized by unprovoked seizures. γ-
Aminobutyric acid (GABA) serves as the primary fast inhibitory neurotransmitter in the brain …
Aminobutyric acid (GABA) serves as the primary fast inhibitory neurotransmitter in the brain …
Role of NKCC1 and KCC2 in epilepsy: from expression to function
R Liu, J Wang, S Liang, G Zhang, X Yang - Frontiers in neurology, 2020 - frontiersin.org
As a main inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid
(GABA) activates chloride-permeable GABAa receptors (GABAa Rs) and induces chloride …
(GABA) activates chloride-permeable GABAa receptors (GABAa Rs) and induces chloride …
[HTML][HTML] Chloride transporters and GABA polarity in developmental, neurological and psychiatric conditions
JT Schulte, CJ Wierenga, H Bruining - Neuroscience & Biobehavioral …, 2018 - Elsevier
Neuronal chloride regulation is a determinant factor for the dynamic tuning of GABAergic
inhibition during and beyond brain development. This regulation is mainly dependent on the …
inhibition during and beyond brain development. This regulation is mainly dependent on the …
Current view on the functional regulation of the neuronal K+-Cl− cotransporter KCC2
I Medina, P Friedel, C Rivera, KT Kahle… - Frontiers in cellular …, 2014 - frontiersin.org
In the mammalian central nervous system (CNS), the inhibitory strength of chloride (Cl−)-
permeable GABAA and glycine receptors (GABAAR and GlyR) depends on the intracellular …
permeable GABAA and glycine receptors (GABAAR and GlyR) depends on the intracellular …
Modulation of neuronal activity by phosphorylation of the K–Cl cotransporter KCC2
KT Kahle, TZ Deeb, M Puskarjov, L Silayeva… - Trends in …, 2013 - cell.com
The K–Cl cotransporter KCC2 establishes the low intraneuronal Cl–levels required for the
hyperpolarizing inhibitory postsynaptic potentials mediated by ionotropic γ-aminobutyric …
hyperpolarizing inhibitory postsynaptic potentials mediated by ionotropic γ-aminobutyric …
Functional organization of extraocular motoneurons and eye muscles
AKE Horn, H Straka - Annual review of vision science, 2021 - annualreviews.org
Eye movements are indispensable for visual image stabilization during self-generated and
passive head and body motion and for visual orientation. Eye muscles and neuronal control …
passive head and body motion and for visual orientation. Eye muscles and neuronal control …
A variant of KCC2 from patients with febrile seizures impairs neuronal Cl− extrusion and dendritic spine formation
M Puskarjov, P Seja, SE Heron, TC Williams… - EMBO …, 2014 - embopress.org
Genetic variation in SLC 12A5 which encodes KCC 2, the neuron‐specific cation‐chloride
cotransporter that is essential for hyperpolarizing GABA ergic signaling and formation of …
cotransporter that is essential for hyperpolarizing GABA ergic signaling and formation of …