Chronic kidney disease (CKD) is prevalent in 9.1% of the global population and is a
significant public health problem associated with increased morbidity and mortality. CKD is …

Background Many modern pharmaceutical researchers continue to focus on the discovery
and evaluation of natural compounds for possible therapies for obesity, diabetes, infections …

Tyrosine kinase inhibitors (TKIs) have vastly improved long-term outcomes for patients with
chronic myeloid leukemia (CML). After imatinib (a first-generation TKI), second-and third …

Obesity-induced adipose dysfunction is a major contributor to atherosclerosis. Cold
exposure has been reported to affect atherosclerosis through regulation of adipose function …

Adipose, or fat, tissue (AT) was once considered an inert tissue that primarily existed to store
lipids, and was not historically recognized as an important organ in the regulation and …

Leptin (LEP) can cross the blood–brain barrier and facilitate cross-talk between the adipose
tissue and central nerve system (CNS). This study aimed to investigate the effect of 8-week …

Non-alcoholic fatty liver disease (NAFLD) has reached epidemic proportions, affecting an
estimated one-quarter of the world's adult population. Multiple organ systems have been …

Alcohol consumption has long been a part of human culture. However, alcohol consumption
levels and alcohol consumption patterns are associated with chronic diseases. Overall, light …

In metabolic conditions such as obesity and diabetes, which are associated with
deregulated signaling of the insulin/insulin-like growth factor system (IIGFs), inflammation …

The prevalence of obesity is rapidly increasing worldwide. Obesity should not be understood
only as the accumulation of fat in the body, but instead as a phenomenon that exerts …