Antibiotic resistance in Pseudomonas aeruginosa–Mechanisms, epidemiology and evolution

J Botelho, F Grosso, L Peixe - Drug resistance updates, 2019 - Elsevier
Antibiotics are powerful drugs used in the treatment of bacterial infections. The inappropriate
use of these medicines has driven the dissemination of antibiotic resistance (AR) in most …

Strategies to combat antimicrobial resistance: anti-plasmid and plasmid curing

MMC Buckner, ML Ciusa… - FEMS microbiology …, 2018 - academic.oup.com
Antimicrobial resistance (AMR) is a global problem hindering treatment of bacterial
infections, rendering many aspects of modern medicine less effective. AMR genes (ARGs) …

Plasmid persistence: costs, benefits, and the plasmid paradox

AC Carroll, A Wong - Canadian journal of microbiology, 2018 - cdnsciencepub.com
Plasmids are extrachromosomal DNA elements that can be found throughout bacteria, as
well as in other domains of life. Nonetheless, the evolutionary processes underlying the …

[HTML][HTML] Bacterial cooperation through horizontal gene transfer

IPA Lee, OT Eldakar, JP Gogarten… - Trends in ecology & …, 2022 - cell.com
Cooperation exists across all scales of biological organization, from genetic elements to
complex human societies. Bacteria cooperate by secreting molecules that benefit all …

PLASMe: a tool to identify PLASMid contigs from short-read assemblies using transformer

X Tang, J Shang, Y Ji, Y Sun - Nucleic Acids Research, 2023 - academic.oup.com
Plasmids are mobile genetic elements that carry important accessory genes. Cataloging
plasmids is a fundamental step to elucidate their roles in promoting horizontal gene transfer …

Expanded Diversity and Phylogeny of mer Genes Broadens Mercury Resistance Paradigms and Reveals an Origin for MerA Among Thermophilic Archaea

CA Christakis, T Barkay, ES Boyd - Frontiers in microbiology, 2021 - frontiersin.org
Mercury (Hg) is a highly toxic element due to its high affinity for protein sulfhydryl groups,
which upon binding, can destabilize protein structure and decrease enzyme activity …

Host-specific plasmid evolution explains the variable spread of clinical antibiotic-resistance plasmids

F Benz, AR Hall - Proceedings of the National Academy of …, 2023 - National Acad Sciences
Antibiotic resistance encoded on plasmids is a pressing global health problem. Predicting
which plasmids spread in the long term remains very challenging, even though some key …

Epistatic interactions between the high pathogenicity island and other iron uptake systems shape Escherichia coli extra-intestinal virulence

G Royer, O Clermont, J Marin, B Condamine… - Nature …, 2023 - nature.com
The intrinsic virulence of extra-intestinal pathogenic Escherichia coli is associated with
numerous chromosomal and/or plasmid-borne genes, encoding diverse functions such as …

Emergence of dominant multidrug-resistant bacterial clades: Lessons from history and whole-genome sequencing

EJ Klemm, VK Wong, G Dougan - Proceedings of the …, 2018 - National Acad Sciences
Antibiotic resistance in bacteria has emerged as a global challenge over the past 90 years,
compromising our ability to effectively treat infections. There has been a dramatic increase in …

[HTML][HTML] Role of Lifestyle Medicine in the Prevention and Treatment of Diseases

M Farrokhi, F Taheri, Z Bayat, M Damiri, M Farrokhi… - Kindle, 2024 - preferpub.org
Lifestyle medicine plays a crucial role in both the prevention and treatment of diseases by
addressing modifiable lifestyle factors that significantly impact health outcomes. This …