Simple Summary Boosting effector T cell anti-tumor response remains a challenge, in part
owing to the expression of immune checkpoints and their ligands, such as NKG2A and HLA …

Following the draft sequence of the first human genome over 20 years ago, we have
achieved unprecedented insights into the rules governing its evolution, often with direct …

Many genomic analyses start by aligning sequencing reads to a linear reference genome.
However, linear reference genomes are imperfect, lacking millions of bases of unknown …

This review summarizes the current knowledge on the major histocompatibility complex
(MHC) of the family Felidae. This family comprises an important domestic species, the cat, as …

The immune system has evolved to protect organisms from infections caused by bacteria,
viruses, and parasitic pathogens. In addition, it provides regenerative capacities, tissue …

The leukocyte receptor complex (LRC) encodes a large number of immunoglobulin (Ig)-like
receptors involved in the immune response, particularly in modulating natural killer (NK) cell …

Background Understanding the variation between well and poorly adapted cattle breeds to
local environments and pathogens is essential for breeding cattle with improved climate and …

Cattle, sheep, and goats are the only species outside primates known to have an expanded
and diversified family of killer immunoglobulin-like receptors (KIR). Primate KIR are …

The major histocompatibility complex (MHC) class I region of cattle is both highly
polymorphic and, unlike many species, highly variable in gene content between haplotypes …

Background The radiation of mammals at the extinction of the dinosaurs produced a
plethora of new forms—as diverse as bats, dolphins, and elephants—in only 10–20 million …