Osteoarthritis is the most common joint disorder with increasing prevalence due to aging of
the population. Its multi-factorial etiology includes oxidative stress and the overproduction of …

Osteoarthritis (OA) is a joint pathology characterized by progressive cartilage degradation.
Medical care is mainly based on alleviating pain symptoms. Compelling studies report the …

Osteoarthritis (OA) is a whole joint disease driven by abnormal biomechanics and attendant
cell-derived and tissue-derived factors. The disease is multifactorial and polygenic, and its …

Mitochondria are important regulators of cellular function and survival that may have a key
role in aging-related diseases. Mitochondrial DNA (mtDNA) mutations and oxidative …

Objectives: The metabolism of cells in articular joint tissues in normal and pathological
conditions is subject to a complex environmental control. In addition to soluble mediators …

OBJECTIVES: This review is focused on the influence of oxygen and derived reactive
species on chondrocytes aging, metabolic function and chondrogenic phenotype …

Introduction Currently available treatments for osteoarthritis (OA) are restricted to
nonsteroidal anti-inflammatory drugs, which exhibit numerous side effects and are only …

Purpose The purpose of this meta-analysis was to compare platelet-rich plasma (PRP) and
hyaluronic acid (HA) in patients with knee osteoarthritis (KOA). Methods Randomized …

Hyaline articular cartilage, the load-bearing tissue of the joint, has very limited repair and
regeneration capacities. The lack of efficient treatment modalities for large chondral defects …

OBJECTIVE: To understand the molecular mechanisms that lead to increased MMP-13
expression and cartilage degeneration during the progression of osteoarthritis (OA), we …