Hypothalamic-pituitary-gonadal (HPG) axis function fundamentally affects the physiology of
eating. We review sex differences in the physiological and pathophysiological controls of …

Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged
as key players in the regulation of reproduction. Mutations in humans or genetically targeted …

Sex hormones exert a profound influence on gendered behaviors. How individual sex
hormone-responsive neuronal populations regulate diverse sex-typical behaviors is unclear …

Kisspeptin is encoded by the Kiss1 gene, and kisspeptin signaling plays a critical role in
reproduction. In rodents, kisspeptin neurons in the arcuate nucleus (Arc) provide tonic drive …

Despite affecting millions of individuals, the etiology of hot flushes remains unknown. Here
we review the physiology of hot flushes, CNS pathways regulating heat-dissipation effectors …

Essential Reproduction provides an accessible account of the fundamentals of reproduction
within the context of cutting-edge knowledge and examples of its application. The eighth …

Mammalian reproductive function depends upon a neuroendocrine circuit that evokes the
pulsatile release of gonadotropin hormones (luteinizing hormone and follicle-stimulating …

Impaired testicular function, ie, hypogonadism, can result from a primary testicular disorder
(hypergonadotropic) or occur secondary to hypothalamic-pituitary dysfunction …

The potential relationship between childhood obesity and earlier puberty onset has major
public health implications. Earlier menarche in girls is associated with increased risk of adult …

Humans and mice with loss-of-function mutations of the genes encoding kisspeptins (Kiss1)
or kisspeptin receptor (Kiss1r) are infertile due to hypogonadotropic hypogonadism. Within …