Oral modified-release multiparticulate dosage forms, which are also referred to as oral
multiple-unit particulate systems, are becoming increasingly popular for oral drug delivery …

In this paper, a compression behavior classification system (CBCS) for direct compression
(DC) pharmaceutical powders is presented. Seven descriptors from a series of compression …

Four granulation techniques were compared evaluating their impact on granule properties
and the tablet tensile strength. A common formulation was chosen to be processed with both …

Direct compaction (DC) is considered to be the most effective method of tablet production.
However, only a small number of the active pharmaceutical ingredients (APIs) can be …

Co-processed excipients may enhance functionality and reduce drawbacks of traditional
excipients for the manufacture of tablets on a commercial scale. The following study aimed …

In this study, the effect of a systematically varied excipient ratio of a plastic and a brittle
material, ie, microcrystalline cellulose (MCC) and crystalline α-lactose monohydrate (LAC) …

This chapter describes the application of lactose as excipient in the pharmaceutical industry.
About 60%–70% of pharmaceutical dosage forms contain lactose, and in volume it is one of …

Dry granulation is an agglomeration process used to produce size-enlarged particles
(granules), improving the handling properties of powders such as flowability. In this process …

The aim of this study was to investigate the correlation between critical granules characters
(including particle size, surface roughness, and apparent porosity) and mechanical …

This work studies the tensile strength, coherence, elastic, and plastic energy of single and bi-
component compacted tablets consisting of (i) microcrystalline cellulose (MCC) PH 102 as a …