The potential role of HIV-1 latency in promoting neuroinflammation and HIV-1-associated neurocognitive disorder
Despite potent suppression of HIV-1 viral replication in the central nervous system (CNS) by
antiretroviral therapy (ART), between 15% and 60% of HIV-1-infected patients receiving ART …
antiretroviral therapy (ART), between 15% and 60% of HIV-1-infected patients receiving ART …
The paradoxical roles of orphan nuclear receptor 4A (NR4A) in cancer
The three-orphan nuclear receptor 4A genes are induced by diverse stressors and stimuli,
and there is increasing evidence that NR4A1 (Nur77), NR4A2 (Nurr1), and NR4A3 (Nor1) …
and there is increasing evidence that NR4A1 (Nur77), NR4A2 (Nurr1), and NR4A3 (Nor1) …
Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease
Triggering receptor expressed on myeloid cells 2 (TREM2) sustains microglia response to
brain injury stimuli including apoptotic cells, myelin damage, and amyloid β (Aβ) …
brain injury stimuli including apoptotic cells, myelin damage, and amyloid β (Aβ) …
Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands
F Haller, M Bieg, R Will, C Körner… - Nature …, 2019 - nature.com
The molecular pathogenesis of salivary gland acinic cell carcinoma (AciCC) is poorly
understood. The secretory Ca-binding phosphoprotein (SCPP) gene cluster at 4q13 …
understood. The secretory Ca-binding phosphoprotein (SCPP) gene cluster at 4q13 …
Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion
L Avery, J Filderman… - Proceedings of the …, 2018 - National Acad Sciences
Tim-3 is highly expressed on a subset of T cells during T cell exhaustion in settings of
chronic viral infection and tumors. Using lymphocytic choriomeningitis virus (LCMV) Clone …
chronic viral infection and tumors. Using lymphocytic choriomeningitis virus (LCMV) Clone …
Nuclear receptor 4A (NR4A) family–orphans no more
S Safe, UH Jin, B Morpurgo, A Abudayyeh… - The Journal of steroid …, 2016 - Elsevier
The orphan nuclear receptors NR4A1, NR4A2 and NR4A3 are immediate early genes
induced by multiple stressors, and the NR4A receptors play an important role in maintaining …
induced by multiple stressors, and the NR4A receptors play an important role in maintaining …
[PDF][PDF] Nuclear receptor Nur77 limits the macrophage inflammatory response through transcriptional reprogramming of mitochondrial metabolism
DS Koenis, L Medzikovic, PB van Loenen… - Cell reports, 2018 - cell.com
Activation of macrophages by inflammatory stimuli induces reprogramming of mitochondrial
metabolism to support the production of pro-inflammatory cytokines and nitric oxide …
metabolism to support the production of pro-inflammatory cytokines and nitric oxide …
PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function
The orphan nuclear receptor Nurr1 is critical for the development, maintenance and
protection of midbrain dopaminergic (mDA) neurons. Here we show that prostaglandin E1 …
protection of midbrain dopaminergic (mDA) neurons. Here we show that prostaglandin E1 …
Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes
Endogenous homeostatic mechanisms can restore normal neuronal function following
cocaine-induced neuroadaptations. Such mechanisms may be exploited to develop novel …
cocaine-induced neuroadaptations. Such mechanisms may be exploited to develop novel …
Flavonoids kaempferol and quercetin are nuclear receptor 4A1 (NR4A1, Nur77) ligands and inhibit rhabdomyosarcoma cell and tumor growth
Background Flavonoids exhibit both chemopreventive and chemotherapeutic activity for
multiple tumor types, however, their mechanisms of action are not well defined. Based on …
multiple tumor types, however, their mechanisms of action are not well defined. Based on …