Calpains are a family of proteases that were scientifically recognized earlier than
proteasomes and caspases, but remain enigmatic. However, they are known to participate in …

Cysteine proteases continue to provide validated targets for treatment of human diseases. In
neurodegenerative disorders, multiple cysteine proteases provide targets for enzyme …

Over the years, researchers in drug discovery have taken advantage of the use of privileged
structures to design innovative hit/lead molecules. The α-ketoamide motif is found in many …

Parkinson's disease (PD) is a progressive, neurodegenerative condition of the central
nervous system (CNS) affecting 6.3 million people worldwide with no curative treatments …

The mitochondrial calcium (Ca2+) uniporter (MCU) mediates high-capacity mitochondrial
Ca2+ uptake implicated in ischemic/reperfusion cell death. We have recently shown that …

T cell development, differentiation, and maintenance are orchestrated by 2 key signaling
axes: the antigen-specific TCR and cytokine-mediated signals. The TCR signals the …

Infections, cancer and autoimmune diseases occur more frequently in the elderly, and
although many factors contribute to this, the age-related remodelling of the immune system …

Pelvic organ prolapse is a frequent health problem in women, encountered worldwide, its
physiopathology being still incompletely understood. The integrity of the pelvic‐supportive …

Axonal degeneration is a major determinant of permanent neurological impairment during
multiple sclerosis (MS). Due to the variable course of clinical disease and the heterogeneity …

Axonal pathology is a key contributor to long‐term disability in multiple sclerosis (MS), an
inflammatory demyelinating disease of the central nervous system (CNS), but the …